A functionalized fluorescent dendrimer as a pesticide nanocarrier: application in pest control

We report the delivery of a hydrophobic pesticide, thiamethoxam, by water-soluble nanosized cationic dendrimers that contain hydrophobic dendritic polyesters and peripheral amines, demonstrated by DLS, spectral analysis and ITC. The dendrimer-based nanocarrier can efficiently deliver the pesticide i...

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Veröffentlicht in:	Nanoscale 2015-01, Vol.7 (2), p.445-449
Hauptverfasser:	Liu, Xiaoxia, He, Bicheng, Xu, Zejun, Yin, Meizhen, Yang, Wantai, Zhang, Huaijiang, Cao, Jingjun, Shen, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines Amines - chemistry Animals Calorimetry Cationic Dendrimers Dendrimers - chemistry Drug Carriers - chemistry Drug delivery systems Hydrophobic and Hydrophilic Interactions Larva - drug effects Lepidoptera - drug effects Lepidoptera - growth & development Light Liver - metabolism Liver - pathology Nanostructure Nanostructures - chemistry Neonicotinoids Nitro Compounds - chemistry Nitro Compounds - metabolism Nitro Compounds - toxicity Oxazines - chemistry Oxazines - metabolism Oxazines - toxicity Pesticides Pesticides - chemistry Pesticides - metabolism Pesticides - toxicity Pests Polyesters - chemistry Scattering, Radiation Spectra Thiazoles - chemistry Thiazoles - metabolism Thiazoles - toxicity
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Beschreibung
Zusammenfassung:	We report the delivery of a hydrophobic pesticide, thiamethoxam, by water-soluble nanosized cationic dendrimers that contain hydrophobic dendritic polyesters and peripheral amines, demonstrated by DLS, spectral analysis and ITC. The dendrimer-based nanocarrier can efficiently deliver the pesticide into the live cells and largely increase the cytotoxicity of the drug.
ISSN:	2040-3364 2040-3372
DOI:	10.1039/c4nr05733c