Prenatal caffeine ingestion induces aberrant DNA methylation and histone acetylation of steroidogenic factor 1 and inhibits fetal adrenal steroidogenesis

Highlights • Prenatal caffeine ingestion inhibits corticosterone production in fetal adrenal. • Prenatal caffeine ingestion inhibits SF-1 and steroidogenic enzymes expression. • Prenatal caffeine ingestion induces abberant DNA methylation of SF-1 promoter. • Prenatal caffeine ingestion induces abber...

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Veröffentlicht in:	Toxicology (Amsterdam) 2014-07, Vol.321, p.53-61
Hauptverfasser:	Ping, Jie, Wang, Jian-fei, Liu, Lian, Yan, You-e, Liu, Fang, Lei, You-ying, Wang, Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adrenal Glands - drug effects Adrenal Glands - embryology Adrenal Glands - metabolism Animals Anti-Inflammatory Agents - pharmacology Caffeine Caffeine - toxicity Central Nervous System Stimulants - toxicity Chromatin Immunoprecipitation Corticosterone - pharmacology Deoxyribonucleic acid DNA methylation DNA Methylation - drug effects Emergency Enzymes Epigenesis, Genetic - drug effects Female Fetal adrenal Gene expression Histone acetylation Histones Histones - metabolism Immunohistochemistry Ingestion Intrauterine growth retardation (IUGR) Methylation Pregnancy Rats Rats, Wistar Real-Time Polymerase Chain Reaction RNA Steroidogenic Factor 1 - metabolism Steroidogenic factor-1 (SF-1) Steroids - biosynthesis
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Zusammenfassung:	Highlights • Prenatal caffeine ingestion inhibits corticosterone production in fetal adrenal. • Prenatal caffeine ingestion inhibits SF-1 and steroidogenic enzymes expression. • Prenatal caffeine ingestion induces abberant DNA methylation of SF-1 promoter. • Prenatal caffeine ingestion induces abberant histone acetylation of SF-1 promoter.
ISSN:	0300-483X 1879-3185
DOI:	10.1016/j.tox.2014.03.011