Complete inhibition of SIVmac replication by its capsid mutants

Mutations were introduced into a genomic region encoding the C-terminal portion of Gag capsid protein of pathogenic simian immunodeficiency virus (SIVmac239). All the mutants generated were defective for virion production and were non-infectious for monkey cells. They all efficiently suppressed the...

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Veröffentlicht in:	Virus genes 1998, Vol.17 (1), p.43-48
Hauptverfasser:	Shimano, R, Inubushi, R, Amano, K, Ogasawara, T, Akari, H, Koyama, A H, Kawamura, M, Adachi, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Capsid - genetics Cell Line, Transformed Chloramphenicol O-Acetyltransferase - genetics Chloramphenicol O-Acetyltransferase - metabolism Defective Viruses - genetics DNA, Viral - genetics Eukaryotic Cells - cytology Eukaryotic Cells - metabolism Eukaryotic Cells - virology HeLa Cells Humans Macaca mulatta Mutagenesis, Site-Directed Mutation RNA-Directed DNA Polymerase - metabolism Simian Immunodeficiency Virus - genetics Virus Replication
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Beschreibung
Zusammenfassung:	Mutations were introduced into a genomic region encoding the C-terminal portion of Gag capsid protein of pathogenic simian immunodeficiency virus (SIVmac239). All the mutants generated were defective for virion production and were non-infectious for monkey cells. They all efficiently suppressed the replication of wild type SIVmac in monkey cells. These results were in good agreement with those obtained for human immunodeficiency virus type 1, showing the importance of SIV/monkey model system for studies on Gag.
ISSN:	0920-8569
DOI:	10.1023/A:1008001000878