Sister chromatid exchange (SCE) and micronucleus (MN) frequencies in lymphocytes of gasoline station attendants

Peripheral blood lymphocytes from 22 men with low average exposure (229 μg/m3=0.72 ppm) to benzene and 19 control men were investigated for Sister Chromatid Exchange (SCE) frequency. The majority of the men (21 exposed, 19 controls) were also investigated using the micronucleus assay (MN). The expos...

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Veröffentlicht in:	Mutation research 1998-07, Vol.415 (1-2), p.25-33
Hauptverfasser:	Bukvic, Nenad, Bavaro, Pietro, Elia, Giuseppe, Cassano, Filippo, Fanelli, Margherita, Guanti, Ginevra
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzene Benzene - adverse effects Biological and medical sciences Cells, Cultured Chemical and industrial products toxicology. Toxic occupational diseases Gas, fumes Gasoline - adverse effects Gasoline station attendant Human biomonitoring Humans Lymphocytes - drug effects Male Medical sciences Micronucleus Micronucleus Tests Mutagens - adverse effects Occupational Exposure Sister Chromatid Exchange Toxicology
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Zusammenfassung:	Peripheral blood lymphocytes from 22 men with low average exposure (229 μg/m3=0.72 ppm) to benzene and 19 control men were investigated for Sister Chromatid Exchange (SCE) frequency. The majority of the men (21 exposed, 19 controls) were also investigated using the micronucleus assay (MN). The exposed subjects were employed at 10 different gas stations in or near the city (Bari/South Italy). SCE frequencies were significantly related with age and smoking habits, on the contrary no relation was observed between SCE and length of employment (SCE=7.41+0.03·age ()+0.0001·length of employment (n.s.)+0.03·cigarette consumption (); F=4.87; p
ISSN:	1383-5718 0027-5107 1879-3592
DOI:	10.1016/S1383-5718(98)00045-X