Microbial transformation of immunosuppressive compounds. I. Desmethylation of FK 506 and immunomycin (FR 900520) by Actinoplanes sp. ATCC 53771

Microbial transformation of immunosuppressive compounds. I. Desmethylation of FK 506 and immunomycin (FR 900520) by Actinoplanes sp. ATCC 53771

The immunosuppressants FK 506 and FR 900520 were desmethylated by Actinoplanes sp. ATCC 53771 to yield various O-desmethylated products. The products were isolated and purified by solvent extraction and HPLC chromatography, and identified by NMR and MS spectroscopy.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of antibiotics 1992, Vol.45 (1), p.118-123
Hauptverfasser: CHEN, TOM S., ARISON, BYRON H., WICKER, LINDA S., INAMINE, EDWARD S., MONAGHAN, RICHARD L.
Format: Artikel
Sprache:eng
Schlagworte:
Actinoplanes
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Zusammenfassung:The immunosuppressants FK 506 and FR 900520 were desmethylated by Actinoplanes sp. ATCC 53771 to yield various O-desmethylated products. The products were isolated and purified by solvent extraction and HPLC chromatography, and identified by NMR and MS spectroscopy.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.45.118