Inhibitory Effects of Ellagic Acid on Glucosyltransferases from Mutans Streptococci

Inhibitory Effects of Ellagic Acid on Glucosyltransferases from Mutans Streptococci

Ellagic acid and its derivatives were found to abrogate the enzymatic activity of the glucosyltransferases (GTases) of mutans streptococci. These compounds preferentially inhibited the water-soluble glucan synthesis by GTase of Streptococcus mutans MT8148 and inhibited the water-insoluble glucan syn...

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Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1992, Vol.56 (5), p.766-768
Hauptverfasser: Sawamura, Shoichiro, Tonosaki, Yasuhiro, Hamada, Shigeyuki
Format: Artikel
Sprache:eng
Schlagworte:
Action of physical and chemical agents on bacteria
Bacteriology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Microbiology
Streptococcus mutans
Streptococcus sobrinus
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Zusammenfassung:Ellagic acid and its derivatives were found to abrogate the enzymatic activity of the glucosyltransferases (GTases) of mutans streptococci. These compounds preferentially inhibited the water-soluble glucan synthesis by GTase of Streptococcus mutans MT8148 and inhibited the water-insoluble glucan synthesis by GTase of Streptococcus sobrinus 6715. This inhibition resulted in a reduction of cellular adherence of mutans streptococci to a glass surface.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.56.766