Effects of antioxidants on streptozotocin-induced clastogenesis in mammalian and insect cells

The effects of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and the hydroxyl radical scavenger mannitol (MAN) on the clastogenesis induced by STZ in Chinese hamster ovary (CHO) and mosquito cells were investigated. The addition of liposome-entrapped SOD, CAT and MAN to both cel...

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Veröffentlicht in:	Mutation research 1998-09, Vol.418 (1), p.35-42
Hauptverfasser:	Bolzán, Alejandro D., Bianchi, Néstor O., Bianchi, Martha S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aedes - cytology Aedes - drug effects Animals Antioxidants - pharmacology Biological and medical sciences Catalase Catalase - pharmacology Cell Line CHO Cells Chromosomal aberration Chromosome Aberrations Cricetinae Drug toxicity and drugs side effects treatment Free Radical Scavengers - pharmacology Hydroxyl Radical Mannitol Mannitol - pharmacology Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Mutagens - toxicity Pharmacology. Drug treatments Streptozocin - toxicity Streptozotocin Superoxide dismutase Superoxide Dismutase - pharmacology
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Zusammenfassung:	The effects of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and the hydroxyl radical scavenger mannitol (MAN) on the clastogenesis induced by STZ in Chinese hamster ovary (CHO) and mosquito cells were investigated. The addition of liposome-entrapped SOD, CAT and MAN to both cell lines caused a significant decrease in the yield of STZ-induced chromosome aberrations ( p
ISSN:	1383-5718 0027-5107 1879-3592
DOI:	10.1016/S1383-5718(98)00107-7