Kinetic resolution for optically active epoxides by microbial enantioselective hydrolysis

Kinetic resolution for optically active epoxides by microbial enantioselective hydrolysis

Resolution of several racemic epoxides was accomplished using an epoxide hydrolase activity of whole cells of the newly isolated Aspergillus niger. (S)-Styrene oxide, for example, was obtained from its racemates with optical purity of 100% ee and 32% yield.

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Veröffentlicht in:Biotechnology techniques 1998, Vol.12 (3), p.225-228
Hauptverfasser: Choi, W.J, Huh, E.C, Park, H.J, Lee, E.Y, Choi, C.Y
Format: Artikel
Sprache:eng
Schlagworte:
Aspergillus niger
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
epoxide hydrolase
Fundamental and applied biological sciences. Psychology
hydrolases
Methods. Procedures. Technologies
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Zusammenfassung:Resolution of several racemic epoxides was accomplished using an epoxide hydrolase activity of whole cells of the newly isolated Aspergillus niger. (S)-Styrene oxide, for example, was obtained from its racemates with optical purity of 100% ee and 32% yield.
ISSN:0951-208X
1573-6784
DOI:10.1023/a:1008825508904