Pharmacological blockage and P2X7 deletion hinder aversive memories: Reversion in an enriched environment

Highlights • P2X7 receptor deletion impaired two memory tasks in rodent models. • Pharmacological blockade of P2X7 receptor hindered conditioned memory. • Enriched environment revert drawbacks caused by P2X7 blocked receptors.

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Veröffentlicht in:	Neuroscience 2014-11, Vol.280, p.220-230
Hauptverfasser:	Campos, R.C, Parfitt, G.M, Polese, C.E, Coutinho-Silva, R, Morrone, F.B, Barros, D.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - pharmacology Animals aversive memory Biological and medical sciences CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - physiology Conditioning (Psychology) - drug effects Conditioning (Psychology) - physiology Dose-Response Relationship, Drug Environment Fear - drug effects Fear - physiology fear conditioning Fundamental and applied biological sciences. Psychology Habituation, Psychophysiologic - drug effects Habituation, Psychophysiologic - physiology Housing, Animal Male Maze Learning - drug effects Maze Learning - physiology Memory - drug effects Memory - physiology Mice, Inbred C57BL Mice, Knockout Neurology P2X7 Pain Threshold - drug effects Pain Threshold - physiology Purinergic P2X Receptor Antagonists - pharmacology purinergic system Quinolines - pharmacology Random Allocation Rats, Wistar Receptors, Purinergic P2X7 - genetics Receptors, Purinergic P2X7 - physiology spatial memory Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights • P2X7 receptor deletion impaired two memory tasks in rodent models. • Pharmacological blockade of P2X7 receptor hindered conditioned memory. • Enriched environment revert drawbacks caused by P2X7 blocked receptors.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.09.017