Inhibited Apoptosis of C2C12 Myoblasts by a Eupatorium chinense var. simplicifolium Root Extract

Inhibited Apoptosis of C2C12 Myoblasts by a Eupatorium chinense var. simplicifolium Root Extract

We investigated the effects of a Eupatorium chinense var. simplicifolium (EUC) root extract on muscle disorders and explored the underlying mechanism for oxidative stress-induced C 2 C 12 myoblast damage. An EUC pre-treatment reduced the decreased cell viability after an H 2 O 2 treatment. The heat...

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Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2013, Vol.77 (10), p.2134-2136
Hauptverfasser: LEE, Jin-Ho, JUNG, Min-Ho, LEE, Yong-Hyeon, SHIN, Yusu, KIM, Han-Sung, SCHREIBER, Jürgen, KIM, Tack-Joong
Format: Artikel
Sprache:eng
Schlagworte:
Eupatorium
Eupatorium chinense var. simplicifolium
HSP70
muscle atrophy
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Zusammenfassung:We investigated the effects of a Eupatorium chinense var. simplicifolium (EUC) root extract on muscle disorders and explored the underlying mechanism for oxidative stress-induced C 2 C 12 myoblast damage. An EUC pre-treatment reduced the decreased cell viability after an H 2 O 2 treatment. The heat shock protein (HSP) 70 level increased, and the phosphorylation of Jun amino-terminal kinases (JNKs) decreased in the EUC-pre-treated C 2 C 12 myoblasts. The results of the present study demonstrate the potential benefit of a herbal medicine in treating oxidative stress-related muscle disorders.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.130333