Cannabis and bipolar disorder: does quitting cannabis use during manic/mixed episode improve clinical/functional outcomes?

Objective To examine whether bipolar disorder patients who stop cannabis use during a manic/mixed episode have better clinical and functional outcomes than continued use or never use. Method Data from the European Mania in Bipolar Longitudinal Evaluation of Medication (EMBLEM), a 2‐year prospective observational study in adults with a manic/mixed episode of bipolar disorder, was used. Three cannabis use groups were: current use (between 12‐week and 24‐month visits); no current but previous use (during first 12 weeks); and never use. Associations between cannabis use and outcomes were analyzed using regression models. Results Of 1922 patients analyzed, 6.9% were current users, 4.6% previous users, and 88.5% never users. Clinical outcomes differed between groups (P 0.05), whereas current users had lower recovery (P = 0.004) and remission (P = 0.014), higher recurrence (P = 0.014), greater work impairment (P = 0.016), and were more likely not to be living with partner (P = 0.006) than never users. Conclusion Bipolar patients who stop using cannabis during manic/mixed episode have similar clinical and functional outcomes to never users, while continued use is associated with higher risk of recurrence and poorer functioning.