Paeonol pretreatment attenuates cerebral ischemic injury via upregulating expression of pAkt, Nrf2, HO-1 and ameliorating BBB permeability in mice
Highlights • Focal cerebral ischemia is induced in mice by permanent MCAO. • Paeonol alleviates neurological deficit, brain edema and infarct size. • Paeonol increases anti-oxidant ability. • Paeonol reduces ischemic brain injury via upregulating of pAkt, Nrf2, HO-1 and ameliorating BBB permeability...
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| Veröffentlicht in: | Brain research bulletin 2014-10, Vol.109, p.61-67 |
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| container_title | Brain research bulletin |
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| creator | Zhao, Yuan Fu, Baosheng Zhang, Xiangjian Zhao, Ting Chen, Linyu Zhang, Jian Wang, Xiaolu |
| description | Highlights • Focal cerebral ischemia is induced in mice by permanent MCAO. • Paeonol alleviates neurological deficit, brain edema and infarct size. • Paeonol increases anti-oxidant ability. • Paeonol reduces ischemic brain injury via upregulating of pAkt, Nrf2, HO-1 and ameliorating BBB permeability. |
| doi_str_mv | 10.1016/j.brainresbull.2014.09.008 |
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Fu, Baosheng ; Zhang, Xiangjian ; Zhao, Ting ; Chen, Linyu ; Zhang, Jian ; Wang, Xiaolu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-1ed91cf86cfeb68d8dce06d69110621e8901b140c070794fa3a83cebbdc9a78f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acetophenones - pharmacology</topic><topic>Acetophenones - therapeutic use</topic><topic>Animals</topic><topic>Blood-Brain Barrier - drug effects</topic><topic>Blood-Brain Barrier - metabolism</topic><topic>Capillary Permeability - drug effects</topic><topic>Claudin-5</topic><topic>Claudin-5 - metabolism</topic><topic>Disease Models, Animal</topic><topic>Heme Oxygenase-1 - genetics</topic><topic>Heme Oxygenase-1 - metabolism</topic><topic>HO-1</topic><topic>Infarction, Middle Cerebral Artery - prevention & control</topic><topic>Ischemic stroke</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Neurology</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>NF-E2-Related Factor 2 - genetics</topic><topic>NF-E2-Related Factor 2 - metabolism</topic><topic>Nrf2</topic><topic>Paeonol</topic><topic>pAkt</topic><topic>Proto-Oncogene Proteins c-akt - genetics</topic><topic>Proto-Oncogene Proteins c-akt - metabolism</topic><topic>Spectrum Analysis</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Up-Regulation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Yuan</creatorcontrib><creatorcontrib>Fu, Baosheng</creatorcontrib><creatorcontrib>Zhang, Xiangjian</creatorcontrib><creatorcontrib>Zhao, Ting</creatorcontrib><creatorcontrib>Chen, Linyu</creatorcontrib><creatorcontrib>Zhang, Jian</creatorcontrib><creatorcontrib>Wang, Xiaolu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Yuan</au><au>Fu, Baosheng</au><au>Zhang, Xiangjian</au><au>Zhao, Ting</au><au>Chen, Linyu</au><au>Zhang, Jian</au><au>Wang, Xiaolu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paeonol pretreatment attenuates cerebral ischemic injury via upregulating expression of pAkt, Nrf2, HO-1 and ameliorating BBB permeability in mice</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>109</volume><spage>61</spage><epage>67</epage><pages>61-67</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><abstract>Highlights • Focal cerebral ischemia is induced in mice by permanent MCAO. • Paeonol alleviates neurological deficit, brain edema and infarct size. • Paeonol increases anti-oxidant ability. • Paeonol reduces ischemic brain injury via upregulating of pAkt, Nrf2, HO-1 and ameliorating BBB permeability.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25286445</pmid><doi>10.1016/j.brainresbull.2014.09.008</doi><tpages>7</tpages></addata></record> |
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| subjects | Acetophenones - pharmacology Acetophenones - therapeutic use Animals Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Capillary Permeability - drug effects Claudin-5 Claudin-5 - metabolism Disease Models, Animal Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism HO-1 Infarction, Middle Cerebral Artery - prevention & control Ischemic stroke Male Malondialdehyde - metabolism Mice Mice, Inbred ICR Neurology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nrf2 Paeonol pAkt Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Spectrum Analysis Superoxide Dismutase - metabolism Up-Regulation - drug effects |
| title | Paeonol pretreatment attenuates cerebral ischemic injury via upregulating expression of pAkt, Nrf2, HO-1 and ameliorating BBB permeability in mice |
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