Paeonol pretreatment attenuates cerebral ischemic injury via upregulating expression of pAkt, Nrf2, HO-1 and ameliorating BBB permeability in mice

Highlights • Focal cerebral ischemia is induced in mice by permanent MCAO. • Paeonol alleviates neurological deficit, brain edema and infarct size. • Paeonol increases anti-oxidant ability. • Paeonol reduces ischemic brain injury via upregulating of pAkt, Nrf2, HO-1 and ameliorating BBB permeability...

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Veröffentlicht in:	Brain research bulletin 2014-10, Vol.109, p.61-67
Hauptverfasser:	Zhao, Yuan, Fu, Baosheng, Zhang, Xiangjian, Zhao, Ting, Chen, Linyu, Zhang, Jian, Wang, Xiaolu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetophenones - pharmacology Acetophenones - therapeutic use Animals Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Capillary Permeability - drug effects Claudin-5 Claudin-5 - metabolism Disease Models, Animal Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism HO-1 Infarction, Middle Cerebral Artery - prevention & control Ischemic stroke Male Malondialdehyde - metabolism Mice Mice, Inbred ICR Neurology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nrf2 Paeonol pAkt Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Spectrum Analysis Superoxide Dismutase - metabolism Up-Regulation - drug effects
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Zusammenfassung:	Highlights • Focal cerebral ischemia is induced in mice by permanent MCAO. • Paeonol alleviates neurological deficit, brain edema and infarct size. • Paeonol increases anti-oxidant ability. • Paeonol reduces ischemic brain injury via upregulating of pAkt, Nrf2, HO-1 and ameliorating BBB permeability.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2014.09.008