Resistin 420C/G gene polymorphism on circulating resistin, metabolic risk factors and insulin resistance in adult women

Highlights • 420C/G polymorphism of resistin gene directly correlated to its high circulating level and metabolic risk factors. • 420C/G polymorphism of resistin gene may have an important role in the development of metabolic syndrome. • G variant allele was found to be significantly associated with...

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Veröffentlicht in:	Immunology letters 2014-12, Vol.162 (2), p.287-291
Hauptverfasser:	Kumar, Sandeep, Gupta, Vani, Srivastava, Nidhi, Gupta, Vandana, Mishra, Sameeksha, Mishra, Supriya, Natu Shankar, Madhav, Roy, Uma, Chandra, Abhijit, Negi, M.P.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Allergy and Immunology Atherosclerosis - blood Atherosclerosis - genetics Atherosclerosis - immunology Blood Pressure Female Humans Insulin resistance Metabolic syndrome Metabolic Syndrome - blood Metabolic Syndrome - genetics Metabolic Syndrome - immunology Obesity - blood Obesity - genetics Obesity - immunology Polymorphism, Restriction Fragment Length Promoter Regions, Genetic Resistin - blood Resistin - genetics Resistin - immunology Resistin level Resistin promoter gene polymorphism Risk Factors Triglycerides - blood Triglycerides - immunology
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Beschreibung
Zusammenfassung:	Highlights • 420C/G polymorphism of resistin gene directly correlated to its high circulating level and metabolic risk factors. • 420C/G polymorphism of resistin gene may have an important role in the development of metabolic syndrome. • G variant allele was found to be significantly associated with hyperlipidemia, HOMA-IR and anthropometric variables.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2014.07.009