The roles of ADAM33, ADAM28, IL-13 and IL-4 in the development of lung injuries in children with lethal non-pandemic acute infectious pneumonia

Highlights • Respiratory infections represent a globally cause of mortality in childhood. • The inflammatory response appears to play role in recovery from virus respiratory disease. • The virus-positive group showed stronger immunolabeling for ADAM33, ADAM28, IL-4 and IL-13 ( p < 0.0001 for all variables). • These proteins might play a role in the inflammatory process in lethal non-pandemic acute viral pneumonias. • These proteins might play a role in alveolar pulmonary fibrosis of virus respiratory infection.