Inflammatory cell recruitment after experimental thromboembolic stroke in rats

Highlights • Ischemic stroke leads to significant neutrophil and monocyte/macrophage recruitment. • Microglia remain numerically unchanged but shifted to an immunoreactive phenotype. • Newly characterized T and B cell subpopulations accumulate in ischemia-affected brain. • Precisely because mimickin...

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Veröffentlicht in:	Neuroscience 2014-10, Vol.279, p.139-154
Hauptverfasser:	Lehmann, J, Härtig, W, Seidel, A, Füldner, C, Hobohm, C, Grosche, J, Krueger, M, Michalski, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - physiology Blood-Brain Barrier - immunology Blood-Brain Barrier - physiopathology Brain - immunology Brain Ischemia - immunology Capillary Permeability - physiology cellular recruitment Disease Models, Animal Infarction, Middle Cerebral Artery inflammation Killer Cells, Natural - physiology Macrophages - physiology Male Microglia - physiology Monocytes - physiology Neurology Neutrophils - physiology Random Allocation Rats, Wistar stroke Stroke - immunology T-Lymphocytes - physiology thromboembolic model Thromboembolism
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Zusammenfassung:	Highlights • Ischemic stroke leads to significant neutrophil and monocyte/macrophage recruitment. • Microglia remain numerically unchanged but shifted to an immunoreactive phenotype. • Newly characterized T and B cell subpopulations accumulate in ischemia-affected brain. • Precisely because mimicking human stroke, embolic models qualify for future research.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.08.023