No evidence for role of extracellular choline-acetyltransferase in generation of gamma oscillations in rat hippocampal slices in vitro

Highlights • γ-Oscillations can be induced by physostigmine. • Acetylcholine augments physostigmine-induced γ-oscillations. • Inhibited choline reuptake by hemicholinium-3 facilitates washout of γ-oscillations. • Reduction of γ-oscillations following inhibition of choline-acetyltransferase. • Dose-d...

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Veröffentlicht in:	Neuroscience 2015-01, Vol.284, p.459-469
Hauptverfasser:	Hollnagel, J.O, ul Haq, R, Behrens, C.J, Maslarova, A, Mody, I, Heinemann, U
Format:	Artikel
Sprache:	eng
Schlagworte:	(2-benzoylethyl)-trimethylammonium iodide (BETA) Acetyl Coenzyme A - administration & dosage Acetyl Coenzyme A - metabolism acetyl-CoA acetylcholine Acetylcholine - administration & dosage Acetylcholine - analogs & derivatives Acetylcholine - metabolism Acetylcholine - pharmacology Animals CA3 Region, Hippocampal - drug effects CA3 Region, Hippocampal - enzymology Choline - metabolism Choline O-Acetyltransferase - antagonists & inhibitors Choline O-Acetyltransferase - metabolism Cholinergic Agents - pharmacology Cholinesterase Inhibitors - pharmacology Dose-Response Relationship, Drug Extracellular Space - enzymology Gamma Rhythm - drug effects Gamma Rhythm - physiology Hemicholinium 3 - pharmacology hemicholinium-3 (HC-3) Male Microelectrodes Neurology Neurotransmitter Uptake Inhibitors - pharmacology physostigmine Physostigmine - pharmacology Rats, Wistar Tissue Culture Techniques γ-oscillations in hippocampal area CA3
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Beschreibung
Zusammenfassung:	Highlights • γ-Oscillations can be induced by physostigmine. • Acetylcholine augments physostigmine-induced γ-oscillations. • Inhibited choline reuptake by hemicholinium-3 facilitates washout of γ-oscillations. • Reduction of γ-oscillations following inhibition of choline-acetyltransferase. • Dose-dependent reduction of γ-oscillations by acetyl-CoA.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.10.016