Effect of actual long-term spaceflight on BDNF, TrkB, p75, BAX and BCL-XL genes expression in mouse brain regions

Highlights • Actual spaceflight considerably decreased BCL-XL gene expression in the hypothalamus. • Long-term spaceflight significantly increased BCL-XL gene expression in the hippocampus. • Actual spaceflight considerably reduced BCL-XL gene expression in the striatum. • Shuttle cabin housing also...

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Veröffentlicht in:	Neuroscience 2015-01, Vol.284, p.730-736
Hauptverfasser:	Naumenko, V.S, Kulikov, A.V, Kondaurova, E.M, Tsybko, A.S, Kulikova, E.A, Krasnov, I.B, Shenkman, B.S, Sychev, V.N, Bazhenova, E.Y, Sinyakova, N.A, Popova, N.K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BAX, BCL-XL, BDNF, TrkB, p75 genes expression bcl-2-Associated X Protein - metabolism bcl-X Protein - metabolism Brain - metabolism Brain-Derived Neurotrophic Factor - metabolism environmental stress Gene Expression Housing, Animal Male mice Mice, Inbred C57BL microgravity Neurology Receptor, trkB - metabolism Receptors, Nerve Growth Factor - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Space Flight spaceflight Stress, Physiological - physiology
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Zusammenfassung:	Highlights • Actual spaceflight considerably decreased BCL-XL gene expression in the hypothalamus. • Long-term spaceflight significantly increased BCL-XL gene expression in the hippocampus. • Actual spaceflight considerably reduced BCL-XL gene expression in the striatum. • Shuttle cabin housing also considerably reduced BCL-XL gene expression in the striatum. • Long-term spaceflight failed to affect BAX, BDNF, TrkB and p75 gene expression.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.10.045