Brain iron accumulation exacerbates the pathogenesis of MPTP-induced Parkinson’s disease

Highlights • CP−/− mice and mice that received FAC had high levels of brain iron. • Brain iron accumulation exacerbated TH-positive neurons apoptosis in MPTP-treated mice. • DFO reduced the neuronal damage in MPTP-treated CP−/− mice. • Increased oxidative stress was involved in cell apoptosis exacer...

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Veröffentlicht in:	Neuroscience 2015-01, Vol.284, p.234-246
Hauptverfasser:	You, L.-H, Li, F, Wang, L, Zhao, S.-E, Wang, S.-M, Zhang, L.-L, Zhang, L.-H, Duan, X.-L, Yu, P, Chang, Y.-Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiparkinson Agents - pharmacology Apoptosis - drug effects Apoptosis - physiology bcl-2-Associated X Protein - metabolism Brain - drug effects Brain - physiopathology brain iron Caspase 3 - metabolism Ceruloplasmin - deficiency Ceruloplasmin - genetics ceruloplasmin-knockout mouse Deferoxamine - pharmacology Dopaminergic Neurons - drug effects Dopaminergic Neurons - physiology Ferric Compounds Iron - metabolism Male Mice, Inbred BALB C Mice, Knockout MPTP Poisoning - drug therapy MPTP Poisoning - physiopathology Neurology Oxidative Stress - drug effects Oxidative Stress - physiology Parkinson’s disease Proto-Oncogene Proteins c-bcl-2 - metabolism Quaternary Ammonium Compounds substantia nigra Tyrosine 3-Monooxygenase - metabolism
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Zusammenfassung:	Highlights • CP−/− mice and mice that received FAC had high levels of brain iron. • Brain iron accumulation exacerbated TH-positive neurons apoptosis in MPTP-treated mice. • DFO reduced the neuronal damage in MPTP-treated CP−/− mice. • Increased oxidative stress was involved in cell apoptosis exacerbated by the increased brain iron.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.09.071