HMG-CoA reductase inhibitor rosuvastatin improves abnormal brain electrical activity via mechanisms involving eNOS

Highlights • We evaluated the role of rosuvastatin on brain electrical activity for the first time. • The mechanism of antiepileptic activity of rosuvastatin relies on the activity of eNOS. • We compared anti-epileptic effects of HMG-CoA reductase inhibitors. • We report that epilepsy increases BBB...

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Veröffentlicht in:	Neuroscience 2015-01, Vol.284, p.349-359
Hauptverfasser:	Seker, F.B, Kilic, U, Caglayan, B, Ethemoglu, M.S, Caglayan, A.B, Ekimci, N, Demirci, S, Dogan, A, Oztezcan, S, Sahin, F, Yilmaz, B, Kilic, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - pharmacology Atorvastatin Calcium - pharmacology bcl-2-Associated X Protein - metabolism Blood-Brain Barrier - drug effects Blood-Brain Barrier - physiopathology Brain - drug effects Brain - physiopathology Capillary Permeability - drug effects Capillary Permeability - physiology Caspase 3 - metabolism Disease Models, Animal eNOS epilepsy Epilepsy - drug therapy Epilepsy - physiopathology gene expression HMG-CoA reductase Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Male Neurology Nitric Oxide Synthase Type III - antagonists & inhibitors Nitric Oxide Synthase Type III - metabolism Penicillin G Random Allocation Rats, Sprague-Dawley RNA, Messenger - metabolism rosuvastatin Rosuvastatin Calcium - pharmacology Simvastatin - pharmacology Tumor Suppressor Protein p53 - metabolism
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