HMG-CoA reductase inhibitor rosuvastatin improves abnormal brain electrical activity via mechanisms involving eNOS

Highlights • We evaluated the role of rosuvastatin on brain electrical activity for the first time. • The mechanism of antiepileptic activity of rosuvastatin relies on the activity of eNOS. • We compared anti-epileptic effects of HMG-CoA reductase inhibitors. • We report that epilepsy increases BBB permeability and rosuvastatin reverses it. • We report gene expression profiling under effect of HMG-CoA reductase- and eNOS inhibitor.