The GABA excitatory/inhibitory developmental sequence: A personal journey

Highlights • GABA excitatory/inhibitory developmental sequence is evolutionary conserved. • Excitatory GABA plays a fundamental role in many developmental processes. • The oxytocin-mediated GABA shift during delivery is abolished in autism. • Immature currents including E GABA persist in pathologica...

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Veröffentlicht in:	Neuroscience 2014-10, Vol.279, p.187-219
1. Verfasser:	Ben-Ari, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autistic Disorder - physiopathology Brain - growth & development Brain - physiology Brain - physiopathology delivery developmental sequence excitation inhibition gamma-Aminobutyric Acid - metabolism Humans intracellular chloride Neurology Neurons - physiology
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Beschreibung
Zusammenfassung:	Highlights • GABA excitatory/inhibitory developmental sequence is evolutionary conserved. • Excitatory GABA plays a fundamental role in many developmental processes. • The oxytocin-mediated GABA shift during delivery is abolished in autism. • Immature currents including E GABA persist in pathological conditions. • Therapeutic strategies using selective antagonists of immature currents in adults.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.08.001