Towards the validation of a lung tumorigenesis model with mainstream cigarette smoke inhalation using the A/J mouse

Towards the validation of a lung tumorigenesis model with mainstream cigarette smoke inhalation using the A/J mouse

Highlights ► Reliability of the assay was shown by intra- and inter-laboratory reproducibility. ► Robustness was shown by comparison to historic data. ► Discriminatory power was shown by minimal detectable differences compatible to other assays. ► Gene expression signatures discriminated lung tumors...

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Veröffentlicht in:Toxicology (Amsterdam) 2013-03, Vol.305, p.49-64
Hauptverfasser: Stinn, Walter, Berges, An, Meurrens, Kris, Buettner, Ansgar, Gebel, Stephan, Lichtner, Rosemarie B, Janssens, Kris, Veljkovic, Emilija, Xiang, Yang, Roemer, Ewald, Haussmann, Hans-Juergen
Format: Artikel
Sprache:eng
Schlagworte:
adenocarcinoma
Animals
breathing
carcinogenesis
Cell Proliferation - drug effects
Cigarette mainstream smoke
cigarettes
Discriminatory power
Dose-Response Relationship, Drug
Emergency
Endpoint Determination
Female
gene expression
Gene Expression Regulation, Neoplastic - genetics
Gene expression signature
Inhalation Exposure
larynx
Lung Neoplasms - chemically induced
Lung Neoplasms - pathology
Lung tumorigenesis
Male
Mice
Mice, Inbred A
model validation
Neoplasms - chemically induced
Neoplasms - pathology
Organ Size
Reproducibility of Results
Respiratory System - pathology
risk
RNA, Neoplasm - biosynthesis
RNA, Neoplasm - genetics
Sex Characteristics
Smoking - adverse effects
Smoking - pathology
Tissue Fixation
toxicology
Validation
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Beschreibung
Zusammenfassung:Highlights ► Reliability of the assay was shown by intra- and inter-laboratory reproducibility. ► Robustness was shown by comparison to historic data. ► Discriminatory power was shown by minimal detectable differences compatible to other assays. ► Gene expression signatures discriminated lung tumors in smoke-exposed and control mice.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2013.01.005