β-Catenin is required for maintaining hippocampal morphology during the perinatal period
Highlights • β-Catenin conditional knockout mice exhibit severe defects of the hippocampus. • Deletion of β-catenin causes ectopic migration of hippocampal cells at E18. • Deletion of β-catenin leads to abnormal radial glial scaffold at DG domain. • β-Catenin domain is occupied by radial glial cells...
Gespeichert in:
| Veröffentlicht in: | Neuroscience 2015-01, Vol.284, p.273-282 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 282 |
|---|---|
| container_issue | |
| container_start_page | 273 |
| container_title | Neuroscience |
| container_volume | 284 |
| creator | Wang, H.-T Zeng, L Chen, Q Zhang, X Liu, J.-W Lu, T.-J Xiong, Z.-Q Zheng, J Hu, Z.-L |
| description | Highlights • β-Catenin conditional knockout mice exhibit severe defects of the hippocampus. • Deletion of β-catenin causes ectopic migration of hippocampal cells at E18. • Deletion of β-catenin leads to abnormal radial glial scaffold at DG domain. • β-Catenin domain is occupied by radial glial cells at P0 in β-catenin CKO mice. |
| doi_str_mv | 10.1016/j.neuroscience.2014.08.055 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1647007139</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0306452214008276</els_id><sourcerecordid>1647007139</sourcerecordid><originalsourceid>FETCH-LOGICAL-c468t-b2afd88a3db90699973cee695dbbeaf3f14ff7640ef464a8b87439af2764c3583</originalsourceid><addsrcrecordid>eNqNksGKFDEQhoMo7uzqK0jjyUuPlU46nXgQZHRVWPCgHjyFdLqyk7G705t0C_NaPojPZJoZRTxtIKRI_VUF31-EPKewpUDFy8N2xCWGZD2OFrcVUL4FuYW6fkA2VDasbGrOH5INMBAlr6vqglymdIB8as4ek4uqrhQAhQ359utnuTMzjn4sfCoi3i0-Yle4EIvB-HHO14-3xd5PU7BmmExfDCFO-9CH22PRLXHNznssJsyhmXN-jUL3hDxypk_49Pxeka_X777sPpQ3n95_3L25KS0Xci7byrhOSsO6VoFQSjXMIgpVd22LxjFHuXON4ICOC25kKxvOlHFV_rOsluyKvDj1nWK4WzDNevDJYt-bEcOSNBW8AWgoU_eQMsWVqAXN0lcnqc2gU0Snp-gHE4-agl5d0Af9rwt6dUGD1NmFXPzsPGdpB-z-lv7BngVvTwLMYH54jPrcpsvw7ay74O835_V_bWyf7bKm_45HTIewxDGj11SnSoP-vO7Dug6UA8gMkP0G7DG2ag</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1639496561</pqid></control><display><type>article</type><title>β-Catenin is required for maintaining hippocampal morphology during the perinatal period</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>Wang, H.-T ; Zeng, L ; Chen, Q ; Zhang, X ; Liu, J.-W ; Lu, T.-J ; Xiong, Z.-Q ; Zheng, J ; Hu, Z.-L</creator><creatorcontrib>Wang, H.-T ; Zeng, L ; Chen, Q ; Zhang, X ; Liu, J.-W ; Lu, T.-J ; Xiong, Z.-Q ; Zheng, J ; Hu, Z.-L</creatorcontrib><description>Highlights • β-Catenin conditional knockout mice exhibit severe defects of the hippocampus. • Deletion of β-catenin causes ectopic migration of hippocampal cells at E18. • Deletion of β-catenin leads to abnormal radial glial scaffold at DG domain. • β-Catenin domain is occupied by radial glial cells at P0 in β-catenin CKO mice.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/j.neuroscience.2014.08.055</identifier><identifier>PMID: 25290010</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Animals ; Basic Helix-Loop-Helix Transcription Factors - metabolism ; beta Catenin - genetics ; beta Catenin - metabolism ; Calbindins - metabolism ; ectopic cell ; Ependymoglial Cells - cytology ; Ependymoglial Cells - metabolism ; Fluorescent Antibody Technique ; GFAP ; Glial Fibrillary Acidic Protein ; hippocampal primordium ; Hippocampus - abnormalities ; Hippocampus - cytology ; Hippocampus - growth & development ; Hippocampus - metabolism ; Homeodomain Proteins - metabolism ; In Situ Hybridization ; Mice, Knockout ; Nerve Tissue Proteins - metabolism ; Neurology ; Neurons - cytology ; Neurons - metabolism ; Neuropilin-2 - metabolism ; Nuclear Proteins - metabolism ; perinatal stage ; radial glial scaffold ; Real-Time Polymerase Chain Reaction ; RNA, Messenger - metabolism ; Tumor Suppressor Proteins - metabolism ; β-catenin</subject><ispartof>Neuroscience, 2015-01, Vol.284, p.273-282</ispartof><rights>IBRO</rights><rights>2014 IBRO</rights><rights>Copyright © 2014 IBRO. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-b2afd88a3db90699973cee695dbbeaf3f14ff7640ef464a8b87439af2764c3583</citedby><cites>FETCH-LOGICAL-c468t-b2afd88a3db90699973cee695dbbeaf3f14ff7640ef464a8b87439af2764c3583</cites><orcidid>0000-0002-7629-360X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuroscience.2014.08.055$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25290010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, H.-T</creatorcontrib><creatorcontrib>Zeng, L</creatorcontrib><creatorcontrib>Chen, Q</creatorcontrib><creatorcontrib>Zhang, X</creatorcontrib><creatorcontrib>Liu, J.-W</creatorcontrib><creatorcontrib>Lu, T.-J</creatorcontrib><creatorcontrib>Xiong, Z.-Q</creatorcontrib><creatorcontrib>Zheng, J</creatorcontrib><creatorcontrib>Hu, Z.-L</creatorcontrib><title>β-Catenin is required for maintaining hippocampal morphology during the perinatal period</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Highlights • β-Catenin conditional knockout mice exhibit severe defects of the hippocampus. • Deletion of β-catenin causes ectopic migration of hippocampal cells at E18. • Deletion of β-catenin leads to abnormal radial glial scaffold at DG domain. • β-Catenin domain is occupied by radial glial cells at P0 in β-catenin CKO mice.</description><subject>Animals</subject><subject>Basic Helix-Loop-Helix Transcription Factors - metabolism</subject><subject>beta Catenin - genetics</subject><subject>beta Catenin - metabolism</subject><subject>Calbindins - metabolism</subject><subject>ectopic cell</subject><subject>Ependymoglial Cells - cytology</subject><subject>Ependymoglial Cells - metabolism</subject><subject>Fluorescent Antibody Technique</subject><subject>GFAP</subject><subject>Glial Fibrillary Acidic Protein</subject><subject>hippocampal primordium</subject><subject>Hippocampus - abnormalities</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - growth & development</subject><subject>Hippocampus - metabolism</subject><subject>Homeodomain Proteins - metabolism</subject><subject>In Situ Hybridization</subject><subject>Mice, Knockout</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Neurology</subject><subject>Neurons - cytology</subject><subject>Neurons - metabolism</subject><subject>Neuropilin-2 - metabolism</subject><subject>Nuclear Proteins - metabolism</subject><subject>perinatal stage</subject><subject>radial glial scaffold</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>RNA, Messenger - metabolism</subject><subject>Tumor Suppressor Proteins - metabolism</subject><subject>β-catenin</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksGKFDEQhoMo7uzqK0jjyUuPlU46nXgQZHRVWPCgHjyFdLqyk7G705t0C_NaPojPZJoZRTxtIKRI_VUF31-EPKewpUDFy8N2xCWGZD2OFrcVUL4FuYW6fkA2VDasbGrOH5INMBAlr6vqglymdIB8as4ek4uqrhQAhQ359utnuTMzjn4sfCoi3i0-Yle4EIvB-HHO14-3xd5PU7BmmExfDCFO-9CH22PRLXHNznssJsyhmXN-jUL3hDxypk_49Pxeka_X777sPpQ3n95_3L25KS0Xci7byrhOSsO6VoFQSjXMIgpVd22LxjFHuXON4ICOC25kKxvOlHFV_rOsluyKvDj1nWK4WzDNevDJYt-bEcOSNBW8AWgoU_eQMsWVqAXN0lcnqc2gU0Snp-gHE4-agl5d0Af9rwt6dUGD1NmFXPzsPGdpB-z-lv7BngVvTwLMYH54jPrcpsvw7ay74O835_V_bWyf7bKm_45HTIewxDGj11SnSoP-vO7Dug6UA8gMkP0G7DG2ag</recordid><startdate>20150122</startdate><enddate>20150122</enddate><creator>Wang, H.-T</creator><creator>Zeng, L</creator><creator>Chen, Q</creator><creator>Zhang, X</creator><creator>Liu, J.-W</creator><creator>Lu, T.-J</creator><creator>Xiong, Z.-Q</creator><creator>Zheng, J</creator><creator>Hu, Z.-L</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><orcidid>https://orcid.org/0000-0002-7629-360X</orcidid></search><sort><creationdate>20150122</creationdate><title>β-Catenin is required for maintaining hippocampal morphology during the perinatal period</title><author>Wang, H.-T ; Zeng, L ; Chen, Q ; Zhang, X ; Liu, J.-W ; Lu, T.-J ; Xiong, Z.-Q ; Zheng, J ; Hu, Z.-L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-b2afd88a3db90699973cee695dbbeaf3f14ff7640ef464a8b87439af2764c3583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Basic Helix-Loop-Helix Transcription Factors - metabolism</topic><topic>beta Catenin - genetics</topic><topic>beta Catenin - metabolism</topic><topic>Calbindins - metabolism</topic><topic>ectopic cell</topic><topic>Ependymoglial Cells - cytology</topic><topic>Ependymoglial Cells - metabolism</topic><topic>Fluorescent Antibody Technique</topic><topic>GFAP</topic><topic>Glial Fibrillary Acidic Protein</topic><topic>hippocampal primordium</topic><topic>Hippocampus - abnormalities</topic><topic>Hippocampus - cytology</topic><topic>Hippocampus - growth & development</topic><topic>Hippocampus - metabolism</topic><topic>Homeodomain Proteins - metabolism</topic><topic>In Situ Hybridization</topic><topic>Mice, Knockout</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Neurology</topic><topic>Neurons - cytology</topic><topic>Neurons - metabolism</topic><topic>Neuropilin-2 - metabolism</topic><topic>Nuclear Proteins - metabolism</topic><topic>perinatal stage</topic><topic>radial glial scaffold</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>RNA, Messenger - metabolism</topic><topic>Tumor Suppressor Proteins - metabolism</topic><topic>β-catenin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, H.-T</creatorcontrib><creatorcontrib>Zeng, L</creatorcontrib><creatorcontrib>Chen, Q</creatorcontrib><creatorcontrib>Zhang, X</creatorcontrib><creatorcontrib>Liu, J.-W</creatorcontrib><creatorcontrib>Lu, T.-J</creatorcontrib><creatorcontrib>Xiong, Z.-Q</creatorcontrib><creatorcontrib>Zheng, J</creatorcontrib><creatorcontrib>Hu, Z.-L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, H.-T</au><au>Zeng, L</au><au>Chen, Q</au><au>Zhang, X</au><au>Liu, J.-W</au><au>Lu, T.-J</au><au>Xiong, Z.-Q</au><au>Zheng, J</au><au>Hu, Z.-L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>β-Catenin is required for maintaining hippocampal morphology during the perinatal period</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2015-01-22</date><risdate>2015</risdate><volume>284</volume><spage>273</spage><epage>282</epage><pages>273-282</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><abstract>Highlights • β-Catenin conditional knockout mice exhibit severe defects of the hippocampus. • Deletion of β-catenin causes ectopic migration of hippocampal cells at E18. • Deletion of β-catenin leads to abnormal radial glial scaffold at DG domain. • β-Catenin domain is occupied by radial glial cells at P0 in β-catenin CKO mice.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>25290010</pmid><doi>10.1016/j.neuroscience.2014.08.055</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-7629-360X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-4522 |
| ispartof | Neuroscience, 2015-01, Vol.284, p.273-282 |
| issn | 0306-4522 1873-7544 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1647007139 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Basic Helix-Loop-Helix Transcription Factors - metabolism beta Catenin - genetics beta Catenin - metabolism Calbindins - metabolism ectopic cell Ependymoglial Cells - cytology Ependymoglial Cells - metabolism Fluorescent Antibody Technique GFAP Glial Fibrillary Acidic Protein hippocampal primordium Hippocampus - abnormalities Hippocampus - cytology Hippocampus - growth & development Hippocampus - metabolism Homeodomain Proteins - metabolism In Situ Hybridization Mice, Knockout Nerve Tissue Proteins - metabolism Neurology Neurons - cytology Neurons - metabolism Neuropilin-2 - metabolism Nuclear Proteins - metabolism perinatal stage radial glial scaffold Real-Time Polymerase Chain Reaction RNA, Messenger - metabolism Tumor Suppressor Proteins - metabolism β-catenin |
| title | β-Catenin is required for maintaining hippocampal morphology during the perinatal period |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T10%3A38%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=%CE%B2-Catenin%20is%20required%20for%20maintaining%20hippocampal%20morphology%20during%20the%20perinatal%20period&rft.jtitle=Neuroscience&rft.au=Wang,%20H.-T&rft.date=2015-01-22&rft.volume=284&rft.spage=273&rft.epage=282&rft.pages=273-282&rft.issn=0306-4522&rft.eissn=1873-7544&rft_id=info:doi/10.1016/j.neuroscience.2014.08.055&rft_dat=%3Cproquest_cross%3E1647007139%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1639496561&rft_id=info:pmid/25290010&rft_els_id=1_s2_0_S0306452214008276&rfr_iscdi=true |