β-Catenin is required for maintaining hippocampal morphology during the perinatal period

Highlights • β-Catenin conditional knockout mice exhibit severe defects of the hippocampus. • Deletion of β-catenin causes ectopic migration of hippocampal cells at E18. • Deletion of β-catenin leads to abnormal radial glial scaffold at DG domain. • β-Catenin domain is occupied by radial glial cells...

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Veröffentlicht in:	Neuroscience 2015-01, Vol.284, p.273-282
Hauptverfasser:	Wang, H.-T, Zeng, L, Chen, Q, Zhang, X, Liu, J.-W, Lu, T.-J, Xiong, Z.-Q, Zheng, J, Hu, Z.-L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - metabolism beta Catenin - genetics beta Catenin - metabolism Calbindins - metabolism ectopic cell Ependymoglial Cells - cytology Ependymoglial Cells - metabolism Fluorescent Antibody Technique GFAP Glial Fibrillary Acidic Protein hippocampal primordium Hippocampus - abnormalities Hippocampus - cytology Hippocampus - growth & development Hippocampus - metabolism Homeodomain Proteins - metabolism In Situ Hybridization Mice, Knockout Nerve Tissue Proteins - metabolism Neurology Neurons - cytology Neurons - metabolism Neuropilin-2 - metabolism Nuclear Proteins - metabolism perinatal stage radial glial scaffold Real-Time Polymerase Chain Reaction RNA, Messenger - metabolism Tumor Suppressor Proteins - metabolism β-catenin
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Zusammenfassung:	Highlights • β-Catenin conditional knockout mice exhibit severe defects of the hippocampus. • Deletion of β-catenin causes ectopic migration of hippocampal cells at E18. • Deletion of β-catenin leads to abnormal radial glial scaffold at DG domain. • β-Catenin domain is occupied by radial glial cells at P0 in β-catenin CKO mice.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.08.055