Primary sensory neurons regulate Toll-like receptor-4-dependent activity of glial cells in dorsal root ganglia

Highlights • Isolated dorsal root ganglion neurons suppress cell surface TLR4 on glia. • LPS stimulates COX-2/PGE2 and TNFα in isolated glial cells. • Exogenous PGE2 increases COX-2 and decreases TNFα mRNA expression in DRG cells. • Heat-shocked neurons release factors to increase COX-2 mRNA express...

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Veröffentlicht in:	Neuroscience 2014-10, Vol.279, p.10-22
Hauptverfasser:	Tse, K.-H, Chow, K.B.S, Leung, W.K, Wong, Y.H, Wise, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Communication - physiology Cell Survival - physiology Cells, Cultured Coculture Techniques COX-2 Culture Media, Conditioned - metabolism Cyclooxygenase 2 - metabolism Dinoprostone - metabolism dorsal root ganglia Ganglia, Spinal - immunology Hot Temperature Lipopolysaccharides Male Neuroglia - immunology neuroinflammation Neurology prostaglandin E2 Rats, Sprague-Dawley RNA, Messenger - metabolism satellite glial cells Sensory Receptor Cells - immunology Stress, Physiological TLR4 Toll-Like Receptor 4 - metabolism Tumor Necrosis Factor-alpha - metabolism
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Zusammenfassung:	Highlights • Isolated dorsal root ganglion neurons suppress cell surface TLR4 on glia. • LPS stimulates COX-2/PGE2 and TNFα in isolated glial cells. • Exogenous PGE2 increases COX-2 and decreases TNFα mRNA expression in DRG cells. • Heat-shocked neurons release factors to increase COX-2 mRNA expression.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.08.033