Effect of acute asenapine treatment on Fos expression in the forebrain structures under normal conditions and mild stress preconditioning in the rat

Highlights • Asenapine (ASE) is a novel atypical antipsychotic designated for treatment of schizophrenia. • ASE effect on Fos expression in striatum, septum, nucleus accumbens, and prefrontal cortex was studied. • ASE induced significant Fos expression almost in all the striatal structures analyzed....

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Veröffentlicht in:	Brain research bulletin 2014-09, Vol.108, p.60-66
Hauptverfasser:	Majercikova, Zuzana, Cernackova, Alena, Horvathova, Lubica, Osacka, Jana, Pecenak, Jan, Kiss, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antipsychotic Agents - pharmacology Asenapine Chronic unpredictable variable mild stress (CMS) Fos expression Heterocyclic Compounds, 4 or More Rings - pharmacology Male Neurology Neurons - drug effects Neurons - metabolism Prosencephalon - drug effects Prosencephalon - metabolism Proto-Oncogene Proteins c-fos - metabolism Rat Rats Rats, Wistar Stress, Psychological - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Asenapine (ASE) is a novel atypical antipsychotic designated for treatment of schizophrenia. • ASE effect on Fos expression in striatum, septum, nucleus accumbens, and prefrontal cortex was studied. • ASE induced significant Fos expression almost in all the striatal structures analyzed. • Chronic unpredictable variable mild stress lasting 21 days did not alter the impact of ASE.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2014.08.006