Characterization of spinal cord glial cells in a model of hindlimb unloading in mice

Highlights • Degrees and directions of changes varied in the numbers of GFAP+ and S100B+ astrocytes in specific areas of the spinal cord. • The number of Olig2+ was increased in every studied area of spinal cord, except the CST. • The amounts of Iba1+ and HoxB8+ cells were significantly increased. •...

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Veröffentlicht in:	Neuroscience 2014-11, Vol.280, p.328-339
Hauptverfasser:	Chelyshev, Y.A, Muhamedshina, Y.O, Povysheva, T.V, Shaymardanova, G.F, Rizvanov, A.A, Nigmetzyanova, M.V, Tiapkina, O.V, Bondarenko, N.I, Nikolskiy, E.E, Islamov, R.R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium-Binding Proteins - metabolism Cell Count Fluorescent Antibody Technique Gene Expression Profiling glia Glial Fibrillary Acidic Protein Gray Matter - metabolism Gray Matter - ultrastructure Hindlimb Suspension hindlimb unloading model Homeodomain Proteins - metabolism Lumbar Vertebrae Male Mice, Inbred C57BL Microfilament Proteins - metabolism Microscopy, Electron myelin Myelin Sheath - metabolism Myelin Sheath - ultrastructure Nerve Tissue Proteins - metabolism Neuroglia - metabolism Neuroglia - ultrastructure Neurology Real-Time Polymerase Chain Reaction S100 Calcium Binding Protein beta Subunit - metabolism spinal cord Spinal Cord - metabolism Spinal Cord - ultrastructure White Matter - metabolism White Matter - ultrastructure
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Zusammenfassung:	Highlights • Degrees and directions of changes varied in the numbers of GFAP+ and S100B+ astrocytes in specific areas of the spinal cord. • The number of Olig2+ was increased in every studied area of spinal cord, except the CST. • The amounts of Iba1+ and HoxB8+ cells were significantly increased. • Electron microscopy showed severe alterations in myelin in the white matter of lumbar spinal cord. • Downregulation of the genes responsible for myelin, extracellular matrix, cytoskeleton, and cell adhesion was revealed.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.09.004