A stereological study of dorsal root ganglion cells and nerve root fibers from rats treated with inorganic mercury
Unbiased stereological methods have been used to quantify the effects of inorganic mercury on the morphology of the fifth lumbar dorsal root ganglion cells and nerve root fibers. Adult male Wistar rats were treated with intraperitoneal injections of mercuric chloride (0.15 mg daily) for 30 days. The...
Gespeichert in:
Veröffentlicht in: | Acta neuropathologica 1997-09, Vol.94 (3), p.280-286 |
---|---|
Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 286 |
---|---|
container_issue | 3 |
container_start_page | 280 |
container_title | Acta neuropathologica |
container_volume | 94 |
creator | SCHIØNNING, J. D LARSEN, J. O |
description | Unbiased stereological methods have been used to quantify the effects of inorganic mercury on the morphology of the fifth lumbar dorsal root ganglion cells and nerve root fibers. Adult male Wistar rats were treated with intraperitoneal injections of mercuric chloride (0.15 mg daily) for 30 days. The total numbers and mean volumes of A- and B-cell perikarya were estimated using the optical fractionator and the vertical rotator techniques. The total numbers of myelinated axons in the ventral and the dorsal roots were estimated with the two-dimensional fractionator technique and the areas of axon and myelin were estimated using the two-dimensional nucleator technique. No differences were found for any parameters in experimental and control animals, indicating that inorganic mercury intoxication alters neither the numbers or sizes of dorsal root ganglion cells and nerve root fibers nor the amount of myelin associated with the nerve fibers. |
doi_str_mv | 10.1007/s004010050704 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_16461078</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2415624693</sourcerecordid><originalsourceid>FETCH-LOGICAL-c401t-6711f7293650624e8e72a1d61eeca490e1c215a7c719909404017d42440796603</originalsourceid><addsrcrecordid>eNpdkc1LxDAQxYMoun4cPQoBxVt1kqbJ5ijiFwhe9FxiOl0jbaOTVtn_3iy7CHpKhvfLTN4bxo4FXAgAc5kAFORbBQbUFpsJVcoCqrLcZjMAEIUupdxj-ym950oaVe2yXSut1HY-Y3TF04iEsYuL4F2Xq6lZ8tjyJlLKNcU48oUbFl2IA_fYdYm7oeED0heu1Ta8IiXeUuw5uTHxkdCN2PDvML7xMETK74PnPZKfaHnIdlrXJTzanAfs5fbm-fq-eHy6e7i-eix89jMW2gjRGmlLXYGWCudopBONFojeKQsovBSVM94Ia8GqVQqmUVIpMFZrKA_Y-brvB8XPCdNY9yGtDLgB45RqoZUWYOYZPP0HvseJhvy3WipR5eHalpkq1pSnmBJhW39Q6B0tawH1ahP1n01k_mTTdXrtsfmlN9Fn_Wyju5SDb8kNPqRfTBpjspHyB_kfjow</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2415624693</pqid></control><display><type>article</type><title>A stereological study of dorsal root ganglion cells and nerve root fibers from rats treated with inorganic mercury</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>SCHIØNNING, J. D ; LARSEN, J. O</creator><creatorcontrib>SCHIØNNING, J. D ; LARSEN, J. O</creatorcontrib><description>Unbiased stereological methods have been used to quantify the effects of inorganic mercury on the morphology of the fifth lumbar dorsal root ganglion cells and nerve root fibers. Adult male Wistar rats were treated with intraperitoneal injections of mercuric chloride (0.15 mg daily) for 30 days. The total numbers and mean volumes of A- and B-cell perikarya were estimated using the optical fractionator and the vertical rotator techniques. The total numbers of myelinated axons in the ventral and the dorsal roots were estimated with the two-dimensional fractionator technique and the areas of axon and myelin were estimated using the two-dimensional nucleator technique. No differences were found for any parameters in experimental and control animals, indicating that inorganic mercury intoxication alters neither the numbers or sizes of dorsal root ganglion cells and nerve root fibers nor the amount of myelin associated with the nerve fibers.</description><identifier>ISSN: 0001-6322</identifier><identifier>EISSN: 1432-0533</identifier><identifier>DOI: 10.1007/s004010050704</identifier><identifier>PMID: 9292698</identifier><identifier>CODEN: ANPTAL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Axons ; Axons - drug effects ; Axons - ultrastructure ; Biological and medical sciences ; Cell Count ; Cell Size - drug effects ; Chemical and industrial products toxicology. Toxic occupational diseases ; Cytology ; Dorsal root ganglia ; Fibers ; Ganglia, Spinal - cytology ; Ganglia, Spinal - drug effects ; Ganglia, Spinal - ultrastructure ; Ganglion cells ; Intoxication ; Lymphocytes B ; Male ; Medical sciences ; Mercuric chloride ; Mercury - toxicity ; Metals and various inorganic compounds ; Myelin ; Myelin Sheath - drug effects ; Myelin Sheath - ultrastructure ; Nerve Fibers - drug effects ; Nerve Fibers - ultrastructure ; Nerve Fibers, Myelinated - physiology ; Nerve Fibers, Myelinated - ultrastructure ; Rats ; Rats, Wistar ; Rodents ; Spinal Nerve Roots - drug effects ; Spinal Nerve Roots - ultrastructure ; Tissue Fixation ; Toxicology</subject><ispartof>Acta neuropathologica, 1997-09, Vol.94 (3), p.280-286</ispartof><rights>1997 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 1997.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-6711f7293650624e8e72a1d61eeca490e1c215a7c719909404017d42440796603</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2777079$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9292698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHIØNNING, J. D</creatorcontrib><creatorcontrib>LARSEN, J. O</creatorcontrib><title>A stereological study of dorsal root ganglion cells and nerve root fibers from rats treated with inorganic mercury</title><title>Acta neuropathologica</title><addtitle>Acta Neuropathol</addtitle><description>Unbiased stereological methods have been used to quantify the effects of inorganic mercury on the morphology of the fifth lumbar dorsal root ganglion cells and nerve root fibers. Adult male Wistar rats were treated with intraperitoneal injections of mercuric chloride (0.15 mg daily) for 30 days. The total numbers and mean volumes of A- and B-cell perikarya were estimated using the optical fractionator and the vertical rotator techniques. The total numbers of myelinated axons in the ventral and the dorsal roots were estimated with the two-dimensional fractionator technique and the areas of axon and myelin were estimated using the two-dimensional nucleator technique. No differences were found for any parameters in experimental and control animals, indicating that inorganic mercury intoxication alters neither the numbers or sizes of dorsal root ganglion cells and nerve root fibers nor the amount of myelin associated with the nerve fibers.</description><subject>Animals</subject><subject>Axons</subject><subject>Axons - drug effects</subject><subject>Axons - ultrastructure</subject><subject>Biological and medical sciences</subject><subject>Cell Count</subject><subject>Cell Size - drug effects</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Cytology</subject><subject>Dorsal root ganglia</subject><subject>Fibers</subject><subject>Ganglia, Spinal - cytology</subject><subject>Ganglia, Spinal - drug effects</subject><subject>Ganglia, Spinal - ultrastructure</subject><subject>Ganglion cells</subject><subject>Intoxication</subject><subject>Lymphocytes B</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mercuric chloride</subject><subject>Mercury - toxicity</subject><subject>Metals and various inorganic compounds</subject><subject>Myelin</subject><subject>Myelin Sheath - drug effects</subject><subject>Myelin Sheath - ultrastructure</subject><subject>Nerve Fibers - drug effects</subject><subject>Nerve Fibers - ultrastructure</subject><subject>Nerve Fibers, Myelinated - physiology</subject><subject>Nerve Fibers, Myelinated - ultrastructure</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Spinal Nerve Roots - drug effects</subject><subject>Spinal Nerve Roots - ultrastructure</subject><subject>Tissue Fixation</subject><subject>Toxicology</subject><issn>0001-6322</issn><issn>1432-0533</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkc1LxDAQxYMoun4cPQoBxVt1kqbJ5ijiFwhe9FxiOl0jbaOTVtn_3iy7CHpKhvfLTN4bxo4FXAgAc5kAFORbBQbUFpsJVcoCqrLcZjMAEIUupdxj-ym950oaVe2yXSut1HY-Y3TF04iEsYuL4F2Xq6lZ8tjyJlLKNcU48oUbFl2IA_fYdYm7oeED0heu1Ta8IiXeUuw5uTHxkdCN2PDvML7xMETK74PnPZKfaHnIdlrXJTzanAfs5fbm-fq-eHy6e7i-eix89jMW2gjRGmlLXYGWCudopBONFojeKQsovBSVM94Ia8GqVQqmUVIpMFZrKA_Y-brvB8XPCdNY9yGtDLgB45RqoZUWYOYZPP0HvseJhvy3WipR5eHalpkq1pSnmBJhW39Q6B0tawH1ahP1n01k_mTTdXrtsfmlN9Fn_Wyju5SDb8kNPqRfTBpjspHyB_kfjow</recordid><startdate>19970901</startdate><enddate>19970901</enddate><creator>SCHIØNNING, J. D</creator><creator>LARSEN, J. O</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>19970901</creationdate><title>A stereological study of dorsal root ganglion cells and nerve root fibers from rats treated with inorganic mercury</title><author>SCHIØNNING, J. D ; LARSEN, J. O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-6711f7293650624e8e72a1d61eeca490e1c215a7c719909404017d42440796603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Axons</topic><topic>Axons - drug effects</topic><topic>Axons - ultrastructure</topic><topic>Biological and medical sciences</topic><topic>Cell Count</topic><topic>Cell Size - drug effects</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Cytology</topic><topic>Dorsal root ganglia</topic><topic>Fibers</topic><topic>Ganglia, Spinal - cytology</topic><topic>Ganglia, Spinal - drug effects</topic><topic>Ganglia, Spinal - ultrastructure</topic><topic>Ganglion cells</topic><topic>Intoxication</topic><topic>Lymphocytes B</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mercuric chloride</topic><topic>Mercury - toxicity</topic><topic>Metals and various inorganic compounds</topic><topic>Myelin</topic><topic>Myelin Sheath - drug effects</topic><topic>Myelin Sheath - ultrastructure</topic><topic>Nerve Fibers - drug effects</topic><topic>Nerve Fibers - ultrastructure</topic><topic>Nerve Fibers, Myelinated - physiology</topic><topic>Nerve Fibers, Myelinated - ultrastructure</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Spinal Nerve Roots - drug effects</topic><topic>Spinal Nerve Roots - ultrastructure</topic><topic>Tissue Fixation</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHIØNNING, J. D</creatorcontrib><creatorcontrib>LARSEN, J. O</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Acta neuropathologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCHIØNNING, J. D</au><au>LARSEN, J. O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A stereological study of dorsal root ganglion cells and nerve root fibers from rats treated with inorganic mercury</atitle><jtitle>Acta neuropathologica</jtitle><addtitle>Acta Neuropathol</addtitle><date>1997-09-01</date><risdate>1997</risdate><volume>94</volume><issue>3</issue><spage>280</spage><epage>286</epage><pages>280-286</pages><issn>0001-6322</issn><eissn>1432-0533</eissn><coden>ANPTAL</coden><abstract>Unbiased stereological methods have been used to quantify the effects of inorganic mercury on the morphology of the fifth lumbar dorsal root ganglion cells and nerve root fibers. Adult male Wistar rats were treated with intraperitoneal injections of mercuric chloride (0.15 mg daily) for 30 days. The total numbers and mean volumes of A- and B-cell perikarya were estimated using the optical fractionator and the vertical rotator techniques. The total numbers of myelinated axons in the ventral and the dorsal roots were estimated with the two-dimensional fractionator technique and the areas of axon and myelin were estimated using the two-dimensional nucleator technique. No differences were found for any parameters in experimental and control animals, indicating that inorganic mercury intoxication alters neither the numbers or sizes of dorsal root ganglion cells and nerve root fibers nor the amount of myelin associated with the nerve fibers.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>9292698</pmid><doi>10.1007/s004010050704</doi><tpages>7</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0001-6322 |
ispartof | Acta neuropathologica, 1997-09, Vol.94 (3), p.280-286 |
issn | 0001-6322 1432-0533 |
language | eng |
recordid | cdi_proquest_miscellaneous_16461078 |
source | MEDLINE; Springer Nature - Complete Springer Journals |
subjects | Animals Axons Axons - drug effects Axons - ultrastructure Biological and medical sciences Cell Count Cell Size - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Cytology Dorsal root ganglia Fibers Ganglia, Spinal - cytology Ganglia, Spinal - drug effects Ganglia, Spinal - ultrastructure Ganglion cells Intoxication Lymphocytes B Male Medical sciences Mercuric chloride Mercury - toxicity Metals and various inorganic compounds Myelin Myelin Sheath - drug effects Myelin Sheath - ultrastructure Nerve Fibers - drug effects Nerve Fibers - ultrastructure Nerve Fibers, Myelinated - physiology Nerve Fibers, Myelinated - ultrastructure Rats Rats, Wistar Rodents Spinal Nerve Roots - drug effects Spinal Nerve Roots - ultrastructure Tissue Fixation Toxicology |
title | A stereological study of dorsal root ganglion cells and nerve root fibers from rats treated with inorganic mercury |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-17T07%3A59%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20stereological%20study%20of%20dorsal%20root%20ganglion%20cells%20and%20nerve%20root%20fibers%20from%20rats%20treated%20with%20inorganic%20mercury&rft.jtitle=Acta%20neuropathologica&rft.au=SCHI%C3%98NNING,%20J.%20D&rft.date=1997-09-01&rft.volume=94&rft.issue=3&rft.spage=280&rft.epage=286&rft.pages=280-286&rft.issn=0001-6322&rft.eissn=1432-0533&rft.coden=ANPTAL&rft_id=info:doi/10.1007/s004010050704&rft_dat=%3Cproquest_cross%3E2415624693%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2415624693&rft_id=info:pmid/9292698&rfr_iscdi=true |