A stereological study of dorsal root ganglion cells and nerve root fibers from rats treated with inorganic mercury

Unbiased stereological methods have been used to quantify the effects of inorganic mercury on the morphology of the fifth lumbar dorsal root ganglion cells and nerve root fibers. Adult male Wistar rats were treated with intraperitoneal injections of mercuric chloride (0.15 mg daily) for 30 days. The...

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Veröffentlicht in:Acta neuropathologica 1997-09, Vol.94 (3), p.280-286
Hauptverfasser: SCHIØNNING, J. D, LARSEN, J. O
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LARSEN, J. O
description Unbiased stereological methods have been used to quantify the effects of inorganic mercury on the morphology of the fifth lumbar dorsal root ganglion cells and nerve root fibers. Adult male Wistar rats were treated with intraperitoneal injections of mercuric chloride (0.15 mg daily) for 30 days. The total numbers and mean volumes of A- and B-cell perikarya were estimated using the optical fractionator and the vertical rotator techniques. The total numbers of myelinated axons in the ventral and the dorsal roots were estimated with the two-dimensional fractionator technique and the areas of axon and myelin were estimated using the two-dimensional nucleator technique. No differences were found for any parameters in experimental and control animals, indicating that inorganic mercury intoxication alters neither the numbers or sizes of dorsal root ganglion cells and nerve root fibers nor the amount of myelin associated with the nerve fibers.
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ispartof Acta neuropathologica, 1997-09, Vol.94 (3), p.280-286
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subjects Animals
Axons
Axons - drug effects
Axons - ultrastructure
Biological and medical sciences
Cell Count
Cell Size - drug effects
Chemical and industrial products toxicology. Toxic occupational diseases
Cytology
Dorsal root ganglia
Fibers
Ganglia, Spinal - cytology
Ganglia, Spinal - drug effects
Ganglia, Spinal - ultrastructure
Ganglion cells
Intoxication
Lymphocytes B
Male
Medical sciences
Mercuric chloride
Mercury - toxicity
Metals and various inorganic compounds
Myelin
Myelin Sheath - drug effects
Myelin Sheath - ultrastructure
Nerve Fibers - drug effects
Nerve Fibers - ultrastructure
Nerve Fibers, Myelinated - physiology
Nerve Fibers, Myelinated - ultrastructure
Rats
Rats, Wistar
Rodents
Spinal Nerve Roots - drug effects
Spinal Nerve Roots - ultrastructure
Tissue Fixation
Toxicology
title A stereological study of dorsal root ganglion cells and nerve root fibers from rats treated with inorganic mercury
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