Spontaneous conversion of PrP super(C) to PrP super(Sc)

Octa-repeats of prion proteins (PrP) contain histidine and tryptophan residues which are known to function as ligands for transition metals. It is proposed that the spontaneous conversion of the PrP super(C) (cellular) isoform into PrP super(Sc) (scrapie) isoform may be triggered by the coordination...

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Veröffentlicht in:	FEBS letters 1992-01, Vol.307 (2), p.129-130
1. Verfasser:	Sulkowski, E
Format:	Artikel
Sprache:	eng
Schlagworte:	conversion hypothesis prion protein prions PrP super(C) protein PrP super(Sc) protein stimulation transition metals
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Octa-repeats of prion proteins (PrP) contain histidine and tryptophan residues which are known to function as ligands for transition metals. It is proposed that the spontaneous conversion of the PrP super(C) (cellular) isoform into PrP super(Sc) (scrapie) isoform may be triggered by the coordination of these metals.
ISSN:	0014-5793