Pharmacokinetic modeling of polychlorinated dibenzo-p-dioxins (PCDDs) and furans (PCDFs) in cows

A physiologically based pharmacokinetic (PB-PK) model for 2,3,7,8-TCDD in cows is described. Uptake in tissues appears to be blood flow limited except in adipose. Sensitive model parameters are fat tissue volume and bioavailability. The agreement between predicted and experimental data is fairly goo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemosphere (Oxford) 1994-02, Vol.28 (4), p.711-715
Hauptverfasser:	Derks, H.J.G.M., Berende, P.L.M., Olling, M., Everts, H., Liem, A.K.D., de Jong, A.P.J.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Environmental pollutants toxicology General aspects Medical sciences Toxicology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A physiologically based pharmacokinetic (PB-PK) model for 2,3,7,8-TCDD in cows is described. Uptake in tissues appears to be blood flow limited except in adipose. Sensitive model parameters are fat tissue volume and bioavailability. The agreement between predicted and experimental data is fairly good.
ISSN:	0045-6535 1879-1298
DOI:	10.1016/0045-6535(94)90222-4