Generating iPSCs: Translating Cell Reprogramming Science into Scalable and Robust Biomanufacturing Strategies

Generating iPSCs: Translating Cell Reprogramming Science into Scalable and Robust Biomanufacturing Strategies

Induced pluripotent stem cells (iPSCs) have the potential to transform drug discovery and healthcare in the 21st century. However, successful commercialization will require standardized manufacturing platforms. Here we highlight the need to define standardized practices for iPSC generation and proce...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cell stem cell 2015-01, Vol.16 (1), p.13-17
Hauptverfasser: Silva, Marli, Daheron, Laurence, Hurley, Hannah, Bure, Kim, Barker, Richard, Carr, Andrew J., Williams, David, Kim, Hae-Won, French, Anna, Coffey, Pete J., Cooper-White, Justin J., Reeve, Brock, Rao, Mahendra, Snyder, Evan Y., Ng, Kelvin S., Mead, Benjamin E., Smith, James A., Karp, Jeffrey M., Brindley, David A., Wall, Ivan
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Culture Techniques - methods
Cellular Reprogramming
Humans
Induced Pluripotent Stem Cells - cytology
Reproducibility of Results
Stem Cell Transplantation
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Induced pluripotent stem cells (iPSCs) have the potential to transform drug discovery and healthcare in the 21st century. However, successful commercialization will require standardized manufacturing platforms. Here we highlight the need to define standardized practices for iPSC generation and processing and discuss current challenges to the robust manufacture of iPSC products.
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2014.12.013