The clinical pharmacology of traditional antiepileptic drugs

Despite the availability of newer agents, a number of antiepileptic drugs have continued to be employed reasonably widely, many years after their introduction to human therapeutics. These drugs comprise phenobarbitone and some of its congeners, phenytoin, ethosuximide, carbamazepine, valproate, and...

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Veröffentlicht in:	Epileptic disorders 2014-12, Vol.16 (4), p.395-408
Hauptverfasser:	Vajda, Frank J.E., Eadie, Mervyn J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticonvulsants - chemistry Anticonvulsants - pharmacokinetics Anticonvulsants - therapeutic use benzodiazepines carbamazepine Convulsions & seizures Epilepsy Epilepsy - drug therapy ethosuximide Humans mechanism of action pharmacokinetics phenobarbitone phenytoin Prescription drugs valproate
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Beschreibung
Zusammenfassung:	Despite the availability of newer agents, a number of antiepileptic drugs have continued to be employed reasonably widely, many years after their introduction to human therapeutics. These drugs comprise phenobarbitone and some of its congeners, phenytoin, ethosuximide, carbamazepine, valproate, and certain benzodiazepines. Details of their pharmacological profiles are outlined in the following account.
ISSN:	1294-9361 1950-6945
DOI:	10.1684/epd.2014.0704