Rhabdomyosarcoma infiltrating bone marrow

Rhabdomyosarcoma infiltrating bone marrow

We present a case of 26-year-old male, previously diagnosed as rhabdomyosarcoma (RMS) of perineal region. The peripheral smear showed a leukoerythroblastic picture with an occasional atypical cell. The bone marrow aspirate and biopsy showed monotonous sheets of malignant cells. On immunohistochemist...

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Veröffentlicht in:International journal of hematology 2015-01, Vol.101 (1), p.1-2
Hauptverfasser: Chauhan, Kriti, Jain, Monica, Shukla, Pragya, Grover, R. K.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biopsy
Bone Marrow - metabolism
Bone Marrow - pathology
Fatal Outcome
Hematology
Humans
Images in Hematology
Immunohistochemistry
Male
Medicine
Medicine & Public Health
Neoplasm Invasiveness
Oncology
Rhabdomyosarcoma - diagnosis
Rhabdomyosarcoma - pathology
Rhabdomyosarcoma - therapy
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Beschreibung
Zusammenfassung:We present a case of 26-year-old male, previously diagnosed as rhabdomyosarcoma (RMS) of perineal region. The peripheral smear showed a leukoerythroblastic picture with an occasional atypical cell. The bone marrow aspirate and biopsy showed monotonous sheets of malignant cells. On immunohistochemistry the tumor cells were strongly positive for desmin and negative for CD34 and CD117. This case illustrates the morphology and IHC findings in a case of RMS. Immunostains like CD34 and CD117 should be included to rule out a possibility of acute leukemia.
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-014-1692-x