Indole Alkaloids from Sickingia williamsii Reduce the In-vitro Effects of Morphine Withdrawal in the Guinea-pig

The effect of indole alkaloids from Sickingia williamsii Standi. (Rubiaceae) on the effects of morphine withdrawal have been examined in‐vitro. All the indole alkaloids isolated from S. williamsii (10−4, 5 ×10−5 and 10−5 m) significantly and in a concentration‐dependent manner reduced the effects of...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 1997-07, Vol.49 (7), p.712-714
Hauptverfasser:	CAPASSO, A., AQUINO, R., GAROFALO, L., DE SIMONE, F., SORRENTINO, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - administration & dosage Acetylcholine - pharmacology Alkaloids - pharmacology Alkaloids - therapeutic use Animals Biological and medical sciences Disease Models, Animal Dose-Response Relationship, Drug Electric Stimulation General pharmacology Guinea Pigs Ileum - drug effects Ileum - pathology Indoles - metabolism Indoles - pharmacology Indoles - therapeutic use Male Medical sciences Morphine - adverse effects Morphine Dependence - drug therapy Naloxone - administration & dosage Naloxone - pharmacology Naloxone - therapeutic use Narcotic Antagonists - administration & dosage Narcotic Antagonists - pharmacology Narcotic Antagonists - therapeutic use Narcotics - adverse effects Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Rubiaceae Substance Withdrawal Syndrome - drug therapy
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Zusammenfassung:	The effect of indole alkaloids from Sickingia williamsii Standi. (Rubiaceae) on the effects of morphine withdrawal have been examined in‐vitro. All the indole alkaloids isolated from S. williamsii (10−4, 5 ×10−5 and 10−5 m) significantly and in a concentration‐dependent manner reduced the effects of morphine withdrawal on the guinea‐pig ileum. The results suggest that these alkaloids might be potential anti‐addictive agents.
ISSN:	0022-3573 2042-7158
DOI:	10.1111/j.2042-7158.1997.tb06097.x