Inhibition of nestin suppresses stem cell phenotype of glioblastomas through the alteration of post-translational modification of heat shock protein HSPA8/HSC71

Highlight • High-grade gliomas exhibited the high expression level of nestin, a neuronal stem/progenitor cell marker. • Knockdown of nestin in glioblastoma cells suppressed stemness. • Nestin and heat shock cognate 71 kDa protein (HSC71; gene HSPA8) regulate each other's expression levels or pa...

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Veröffentlicht in:	Cancer letters 2015-02, Vol.357 (2), p.602-611
Hauptverfasser:	Matsuda, Yoko, Ishiwata, Toshiyuki, Yoshimura, Hisashi, Hagio, Masahito, Arai, Tomio
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Animals Antigens, CD - genetics Brain - metabolism Brain - pathology Brain research Cadherins - genetics Cancer Carcinogenesis - genetics Carcinogenesis - metabolism Cell adhesion & migration Cell growth Cell Line, Tumor Dimensional analysis Electrophoresis, Gel, Two-Dimensional Gene Expression Regulation, Neoplastic Genotype & phenotype Glioblastoma Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Glycoproteins - genetics Heat shock cognate 71 kDa protein Hematology, Oncology and Palliative Medicine Homeodomain Proteins - genetics HSC70 Heat-Shock Proteins - genetics HSC70 Heat-Shock Proteins - metabolism Humans Immunohistochemistry Invasion Kinases Male Mass Spectrometry Medical prognosis Medical research Metastasis Mice, Inbred NOD Nanog Homeobox Protein Nestin Nestin - genetics Nestin - metabolism Octamer Transcription Factor-3 - genetics Pathology Peptides - genetics Phenotype Phosphorylation Protein folding Protein Processing, Post-Translational Proteomics - methods R&D Research & development Reverse Transcriptase Polymerase Chain Reaction RNA Interference Stem cells Stem Cells - metabolism Transplantation, Heterologous Tumors
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Zusammenfassung:	Highlight • High-grade gliomas exhibited the high expression level of nestin, a neuronal stem/progenitor cell marker. • Knockdown of nestin in glioblastoma cells suppressed stemness. • Nestin and heat shock cognate 71 kDa protein (HSC71; gene HSPA8) regulate each other's expression levels or patterns. • Inhibition of nestin and HSC71 may be a useful target for glioblastomas.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.12.030