BCG vaccination-induced long-lasting control of Mycobacterium tuberculosis correlates with the accumulation of a novel population of CD4+ IL-17+ TNF+ IL-2+ T cells

Highlights • Mice were vaccinated with BCG for 21 or 120 days before challenged with Mtb. • Mice challenged 120 days after BCG vaccination displayed improved control of Mtb. • BCG-mediated control of Mtb correlates with the IL-17 response and is independent of the magnitude of the IFN-γ response in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2015-01, Vol.33 (1), p.85-91
Hauptverfasser:	Cruz, Andrea, Torrado, Egídio, Carmona, Jenny, Fraga, Alexandra G, Costa, Patrício, Rodrigues, Fernando, Appelberg, Rui, Correia-Neves, Margarida, Cooper, Andrea M, Saraiva, Margarida, Pedrosa, Jorge, Castro, António G
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals BCG vaccination BCG Vaccine - administration & dosage BCG Vaccine - immunology CD4-Positive T-Lymphocytes - immunology Disease Models, Animal Effector CD4+ T cells Immunologic Memory Interleukin-17 - secretion Interleukin-2 - secretion Memory CD4+ T cells Mice, Inbred C57BL Multifunctional CD4+ T cells Mycobacterium bovis Mycobacterium tuberculosis T-Lymphocyte Subsets - immunology Time Factors Tuberculosis Tuberculosis - immunology Tuberculosis - prevention & control Tumor Necrosis Factor-alpha - secretion
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Mice were vaccinated with BCG for 21 or 120 days before challenged with Mtb. • Mice challenged 120 days after BCG vaccination displayed improved control of Mtb. • BCG-mediated control of Mtb correlates with the IL-17 response and is independent of the magnitude of the IFN-γ response in the lung. • Long-lasting control of Mtb correlates with the accumulation of CD4+ T cells producing IL-17, TNF and IL-2.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2014.11.013