A novel peptide-based pan-influenza A vaccine: A double blind, randomised clinical trial of immunogenicity and safety

Highlights • We have developed a peptide-based pan-influenza A vaccine. • This vaccine was tested in a double-blind placebo-controlled clinical trial. • Results showed a good safety and tolerability profile. • The vaccine was immunogenic in most subjects and showed an anti-viral phenotype.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2015-01, Vol.33 (2), p.396-402
Hauptverfasser:	Francis, James N, Bunce, Campbell J, Horlock, Claire, Watson, Jeannette M, Warrington, Steven J, Georges, Bertrand, Brown, Carlton B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergy and Immunology Antibodies, Viral - immunology CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Clinical trials Cross Reactions Cytokines Cytotoxicity Double-Blind Method Enzyme-Linked Immunospot Assay Epitopes, T-Lymphocyte - immunology Flow Cytometry Fluoropeptides Humans Immune response Immunogenicity Influenza Influenza Vaccines - administration & dosage Influenza Vaccines - adverse effects Influenza Vaccines - immunology Influenza, Human - prevention & control Interferon-gamma - biosynthesis Interferon-gamma - immunology Leukocytes, Mononuclear - immunology Lymphocytes Male Middle Aged Pandemics Peptides Perfluorocarbons Safety Studies T cells T-Lymphocytes - immunology Vaccination Vaccine Vaccines Vaccines, Subunit - administration & dosage Vaccines, Subunit - adverse effects Vaccines, Subunit - immunology Young Adult
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Beschreibung
Zusammenfassung:	Highlights • We have developed a peptide-based pan-influenza A vaccine. • This vaccine was tested in a double-blind placebo-controlled clinical trial. • Results showed a good safety and tolerability profile. • The vaccine was immunogenic in most subjects and showed an anti-viral phenotype.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2014.06.006