Latent Acyclovir-Resistant Herpes Simplex Virus Type 1 in Trigeminal Ganglia of Immunocompetent Individuals
Specific mutations within the hypervariable herpes simplex virus (HSV) gene thymidine kinase (TK) gene lead to acyclovir (ACV) resistance. To uncover the existence of latent ACV-resistant (ACV R ) HSV-1, we determined the genetic and functional variability of the HSV-1 TK gene pool in paired trigemi...
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| Veröffentlicht in: | The Journal of infectious diseases 2012-05, Vol.205 (10), p.1539-1543 |
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| container_title | The Journal of infectious diseases |
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| creator | van Velzen, Monique van Loenen, Freek B. Meesters, Roland J. W. de Graaf, Miranda Remeijer, Lies Luider, Theo M. Osterhaus, Albert D. M. E. Verjans, Georges M. G. M. |
| description | Specific mutations within the hypervariable herpes simplex virus (HSV) gene thymidine kinase (TK) gene lead to acyclovir (ACV) resistance. To uncover the existence of latent ACV-resistant (ACV R ) HSV-1, we determined the genetic and functional variability of the HSV-1 TK gene pool in paired trigeminal ganglia (TG) of 5 immunocompetent individuals. The latent virus pool consisted of a donor-specific HSV-1 quasispecies, including one major ACV-sensitive (ACV S ) and multiple phylogenetic-related minor ACV S and ACV R TK variants. Contrary to minor variants, major TK variants were shared between paired TG. The data demonstrate the coexistence of phylogenetic-related ACV S and ACV R latent HSV-1 in human TG. |
| doi_str_mv | 10.1093/infdis/jis237 |
| format | Article |
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W. ; de Graaf, Miranda ; Remeijer, Lies ; Luider, Theo M. ; Osterhaus, Albert D. M. E. ; Verjans, Georges M. G. M.</creator><creatorcontrib>van Velzen, Monique ; van Loenen, Freek B. ; Meesters, Roland J. W. ; de Graaf, Miranda ; Remeijer, Lies ; Luider, Theo M. ; Osterhaus, Albert D. M. E. ; Verjans, Georges M. G. M.</creatorcontrib><description>Specific mutations within the hypervariable herpes simplex virus (HSV) gene thymidine kinase (TK) gene lead to acyclovir (ACV) resistance. To uncover the existence of latent ACV-resistant (ACV R ) HSV-1, we determined the genetic and functional variability of the HSV-1 TK gene pool in paired trigeminal ganglia (TG) of 5 immunocompetent individuals. The latent virus pool consisted of a donor-specific HSV-1 quasispecies, including one major ACV-sensitive (ACV S ) and multiple phylogenetic-related minor ACV S and ACV R TK variants. Contrary to minor variants, major TK variants were shared between paired TG. The data demonstrate the coexistence of phylogenetic-related ACV S and ACV R latent HSV-1 in human TG.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jis237</identifier><identifier>PMID: 22457282</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Acyclovir - pharmacology ; Aged ; Aged, 80 and over ; Amino acids ; Animals ; Antiviral Agents - pharmacology ; Autopsy ; Base Sequence ; Biological and medical sciences ; Cercopithecus aethiops ; COS Cells ; DNA, Viral - genetics ; Drug Resistance, Viral - genetics ; Female ; Fundamental and applied biological sciences. Psychology ; Ganglia ; Genetic mutation ; Herpes Simplex - drug therapy ; Herpes Simplex - virology ; Herpes simplex virus 1 ; Herpesvirus 1, Human - drug effects ; Herpesvirus 1, Human - genetics ; Herpesvirus 1, Human - physiology ; Human genetics ; Human herpesvirus 1 ; Humans ; Immunocompetence ; Infections ; Infectious diseases ; Male ; Medical genetics ; Medical sciences ; Microbiology ; Miscellaneous ; Molecular Sequence Data ; Mutation ; Phylogeny ; Prevalence ; Sequence Analysis, DNA ; Simplexvirus ; Thymidine Kinase - chemistry ; Thymidine Kinase - genetics ; Thymidine Kinase - metabolism ; Trigeminal ganglion ; Trigeminal Ganglion - virology ; Virology ; Virus Latency ; Viruses</subject><ispartof>The Journal of infectious diseases, 2012-05, Vol.205 (10), p.1539-1543</ispartof><rights>Copyright © 2012 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-4334db385d20f47f3d9bd2909c63034c0424927717bbe57bb1cf87c14361609d3</citedby><cites>FETCH-LOGICAL-c417t-4334db385d20f47f3d9bd2909c63034c0424927717bbe57bb1cf87c14361609d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/23216438$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/23216438$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25866522$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22457282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Velzen, Monique</creatorcontrib><creatorcontrib>van Loenen, Freek B.</creatorcontrib><creatorcontrib>Meesters, Roland J. W.</creatorcontrib><creatorcontrib>de Graaf, Miranda</creatorcontrib><creatorcontrib>Remeijer, Lies</creatorcontrib><creatorcontrib>Luider, Theo M.</creatorcontrib><creatorcontrib>Osterhaus, Albert D. M. E.</creatorcontrib><creatorcontrib>Verjans, Georges M. G. M.</creatorcontrib><title>Latent Acyclovir-Resistant Herpes Simplex Virus Type 1 in Trigeminal Ganglia of Immunocompetent Individuals</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Specific mutations within the hypervariable herpes simplex virus (HSV) gene thymidine kinase (TK) gene lead to acyclovir (ACV) resistance. To uncover the existence of latent ACV-resistant (ACV R ) HSV-1, we determined the genetic and functional variability of the HSV-1 TK gene pool in paired trigeminal ganglia (TG) of 5 immunocompetent individuals. The latent virus pool consisted of a donor-specific HSV-1 quasispecies, including one major ACV-sensitive (ACV S ) and multiple phylogenetic-related minor ACV S and ACV R TK variants. Contrary to minor variants, major TK variants were shared between paired TG. The data demonstrate the coexistence of phylogenetic-related ACV S and ACV R latent HSV-1 in human TG.</description><subject>Acyclovir - pharmacology</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Antiviral Agents - pharmacology</subject><subject>Autopsy</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cercopithecus aethiops</subject><subject>COS Cells</subject><subject>DNA, Viral - genetics</subject><subject>Drug Resistance, Viral - genetics</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglia</subject><subject>Genetic mutation</subject><subject>Herpes Simplex - drug therapy</subject><subject>Herpes Simplex - virology</subject><subject>Herpes simplex virus 1</subject><subject>Herpesvirus 1, Human - drug effects</subject><subject>Herpesvirus 1, Human - genetics</subject><subject>Herpesvirus 1, Human - physiology</subject><subject>Human genetics</subject><subject>Human herpesvirus 1</subject><subject>Humans</subject><subject>Immunocompetence</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Phylogeny</subject><subject>Prevalence</subject><subject>Sequence Analysis, DNA</subject><subject>Simplexvirus</subject><subject>Thymidine Kinase - chemistry</subject><subject>Thymidine Kinase - genetics</subject><subject>Thymidine Kinase - metabolism</subject><subject>Trigeminal ganglion</subject><subject>Trigeminal Ganglion - virology</subject><subject>Virology</subject><subject>Virus Latency</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1L7DAUBuAgio4fS5dKNoKbar6aNEuRqw4MCDq6LWmSSsY2rUkrd_690Y66dJMDyZMD57wAHGN0gZGkl87XxsXLlYuEii0wwzkVGeeYboMZQoRkuJByD-zHuEIIMcrFLtgjhOWCFGQGXhdqsH6AV3qtm-7dhezBRhcHle7ubOhthI-u7Rv7Hz67MEa4XPcWYug8XAb3YlvnVQNvlX9pnIJdDedtO_pOd21vvxrPvXHvzoyqiYdgp07FHm3qAXi6-be8vssW97fz66tFphkWQ8YoZaaiRW4IqpmoqZGVIRJJzSmiTCNGmCRCYFFVNk8H1nUhNE6zYY6koQfgfOrbh-5ttHEoWxe1bRrlbTfGEnNGEmWM_E0RkjmmiItEs4nq0MUYbF32wbUqrBMqP6MopyjKKYrkTzetx6q15kd_7z6Bsw1QUaumDsrr9P3H5QXnOfl0J5NbxaELv--UpBloQT8AJfKcsQ</recordid><startdate>20120515</startdate><enddate>20120515</enddate><creator>van Velzen, Monique</creator><creator>van Loenen, Freek B.</creator><creator>Meesters, Roland J. 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Psychology</topic><topic>Ganglia</topic><topic>Genetic mutation</topic><topic>Herpes Simplex - drug therapy</topic><topic>Herpes Simplex - virology</topic><topic>Herpes simplex virus 1</topic><topic>Herpesvirus 1, Human - drug effects</topic><topic>Herpesvirus 1, Human - genetics</topic><topic>Herpesvirus 1, Human - physiology</topic><topic>Human genetics</topic><topic>Human herpesvirus 1</topic><topic>Humans</topic><topic>Immunocompetence</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Phylogeny</topic><topic>Prevalence</topic><topic>Sequence Analysis, DNA</topic><topic>Simplexvirus</topic><topic>Thymidine Kinase - chemistry</topic><topic>Thymidine Kinase - genetics</topic><topic>Thymidine Kinase - metabolism</topic><topic>Trigeminal ganglion</topic><topic>Trigeminal Ganglion - virology</topic><topic>Virology</topic><topic>Virus Latency</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Velzen, Monique</creatorcontrib><creatorcontrib>van Loenen, Freek B.</creatorcontrib><creatorcontrib>Meesters, Roland J. 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The latent virus pool consisted of a donor-specific HSV-1 quasispecies, including one major ACV-sensitive (ACV S ) and multiple phylogenetic-related minor ACV S and ACV R TK variants. Contrary to minor variants, major TK variants were shared between paired TG. The data demonstrate the coexistence of phylogenetic-related ACV S and ACV R latent HSV-1 in human TG.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>22457282</pmid><doi>10.1093/infdis/jis237</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acyclovir - pharmacology Aged Aged, 80 and over Amino acids Animals Antiviral Agents - pharmacology Autopsy Base Sequence Biological and medical sciences Cercopithecus aethiops COS Cells DNA, Viral - genetics Drug Resistance, Viral - genetics Female Fundamental and applied biological sciences. Psychology Ganglia Genetic mutation Herpes Simplex - drug therapy Herpes Simplex - virology Herpes simplex virus 1 Herpesvirus 1, Human - drug effects Herpesvirus 1, Human - genetics Herpesvirus 1, Human - physiology Human genetics Human herpesvirus 1 Humans Immunocompetence Infections Infectious diseases Male Medical genetics Medical sciences Microbiology Miscellaneous Molecular Sequence Data Mutation Phylogeny Prevalence Sequence Analysis, DNA Simplexvirus Thymidine Kinase - chemistry Thymidine Kinase - genetics Thymidine Kinase - metabolism Trigeminal ganglion Trigeminal Ganglion - virology Virology Virus Latency Viruses |
| title | Latent Acyclovir-Resistant Herpes Simplex Virus Type 1 in Trigeminal Ganglia of Immunocompetent Individuals |
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