Latent Acyclovir-Resistant Herpes Simplex Virus Type 1 in Trigeminal Ganglia of Immunocompetent Individuals

Specific mutations within the hypervariable herpes simplex virus (HSV) gene thymidine kinase (TK) gene lead to acyclovir (ACV) resistance. To uncover the existence of latent ACV-resistant (ACV R ) HSV-1, we determined the genetic and functional variability of the HSV-1 TK gene pool in paired trigemi...

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Veröffentlicht in:	The Journal of infectious diseases 2012-05, Vol.205 (10), p.1539-1543
Hauptverfasser:	van Velzen, Monique, van Loenen, Freek B., Meesters, Roland J. W., de Graaf, Miranda, Remeijer, Lies, Luider, Theo M., Osterhaus, Albert D. M. E., Verjans, Georges M. G. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclovir - pharmacology Aged Aged, 80 and over Amino acids Animals Antiviral Agents - pharmacology Autopsy Base Sequence Biological and medical sciences Cercopithecus aethiops COS Cells DNA, Viral - genetics Drug Resistance, Viral - genetics Female Fundamental and applied biological sciences. Psychology Ganglia Genetic mutation Herpes Simplex - drug therapy Herpes Simplex - virology Herpes simplex virus 1 Herpesvirus 1, Human - drug effects Herpesvirus 1, Human - genetics Herpesvirus 1, Human - physiology Human genetics Human herpesvirus 1 Humans Immunocompetence Infections Infectious diseases Male Medical genetics Medical sciences Microbiology Miscellaneous Molecular Sequence Data Mutation Phylogeny Prevalence Sequence Analysis, DNA Simplexvirus Thymidine Kinase - chemistry Thymidine Kinase - genetics Thymidine Kinase - metabolism Trigeminal ganglion Trigeminal Ganglion - virology Virology Virus Latency Viruses
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Zusammenfassung:	Specific mutations within the hypervariable herpes simplex virus (HSV) gene thymidine kinase (TK) gene lead to acyclovir (ACV) resistance. To uncover the existence of latent ACV-resistant (ACV R ) HSV-1, we determined the genetic and functional variability of the HSV-1 TK gene pool in paired trigeminal ganglia (TG) of 5 immunocompetent individuals. The latent virus pool consisted of a donor-specific HSV-1 quasispecies, including one major ACV-sensitive (ACV S ) and multiple phylogenetic-related minor ACV S and ACV R TK variants. Contrary to minor variants, major TK variants were shared between paired TG. The data demonstrate the coexistence of phylogenetic-related ACV S and ACV R latent HSV-1 in human TG.
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/jis237