Improved and optimized one-pot method for N-succinimidyl-4-[(18)F]fluorobenzoate ([(18)F]SFB) synthesis using microwaves

N-Succinimidyl-4-[(18)F]fluorobenzoate ([(18)F]SFB) is a potential prosthetic agent for novel tracer development in positron emission tomography (PET). Previously, we reported a microwave-assisted one-pot synthesis of [(18)F]SFB with high efficacy. Herein, we reveal an improved and optimized approac...

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Veröffentlicht in:	Applied radiation and isotopes 2014-12, Vol.94, p.113-117
Hauptverfasser:	Li, Kang-Po, Hu, Ming-Kuan, Kwang-Fu Shen, Clifton, Lin, Wei-Yu, Hou, Shuang, Zhao, Li-Bo, Cheng, Cheng-Yi, Shen, Daniel H
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzoates - chemical synthesis Benzoates - isolation & purification Diathermy - methods Isotope Labeling - methods Materials Testing Microwaves Radiation Dosage Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - isolation & purification Radiopharmaceuticals - radiation effects Succinimides - chemical synthesis Succinimides - isolation & purification
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Beschreibung
Zusammenfassung:	N-Succinimidyl-4-[(18)F]fluorobenzoate ([(18)F]SFB) is a potential prosthetic agent for novel tracer development in positron emission tomography (PET). Previously, we reported a microwave-assisted one-pot synthesis of [(18)F]SFB with high efficacy. Herein, we reveal an improved and optimized approach based on this former model for producing [(18)F]SFB. With optimized approaches, the entire protocol can be completed within 25min, and [(18)F]SFB is generated in satisfactory quality for direct use without further purification via high-performance liquid chromatography.
ISSN:	0969-8043 1872-9800
DOI:	10.1016/j.apradiso.2014.07.015