Method development and validation for simultaneous quantification of 15 drugs of abuse and prescription drugs and 7 of their metabolites in whole blood relevant in the context of driving under the influence of drugs––Usefulness of multi-analyte calibration

Highlights • Fully validated method for 15 DOAs and medications in whole blood. • No relevant differences between analyte mixtures and single analytes. • Multi-analyte calibration useful for quantification of single analytes.

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Bibliographische Detailangaben
Veröffentlicht in:	Forensic science international 2014-11, Vol.244, p.92-101
Hauptverfasser:	Steuer, Andrea E, Forss, Anna-Maria, Dally, Annika M, Kraemer, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Automobile Driving - legislation & jurisprudence Binding sites Blood Calibration Chromatography, High Pressure Liquid - methods Dopamine Drugs DUID Forensic sciences Guidelines Heroin Humans LC–MS/MS Mass Spectrometry - methods Metabolites Methamphetamine Methods Multi-analyte approach Narcotics Narcotics - blood Pathology Prescription drugs Prescription Drugs - analysis Quality control Recovery Routines Solid Phase Extraction Studies Substance Abuse Detection - methods Validation
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Beschreibung
Zusammenfassung:	Highlights • Fully validated method for 15 DOAs and medications in whole blood. • No relevant differences between analyte mixtures and single analytes. • Multi-analyte calibration useful for quantification of single analytes.
ISSN:	0379-0738 1872-6283
DOI:	10.1016/j.forsciint.2014.08.022