Amphiphilic Star Copolymer-Based Bimodal Fluorogenic/Magnetic Resonance Probes for Concomitant Bacteria Detection and Inhibition

Four‐arm star‐shaped copolymers, TPE‐star‐P(DMA‐co‐BMA‐co‐Gd), containing TPE cores with an aggregation‐induced emission (AIE) feature, a T 1‐type magnetic resonance (MR) contrast agent, and amphiphilic cationic arms, are synthesized. By taking advantage of non‐covalent interactions between star cop...

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Veröffentlicht in:	Advanced materials (Weinheim) 2014-10, Vol.26 (39), p.6734-6741
Hauptverfasser:	Li, Yamin, Yu, Hansen, Qian, Yinfeng, Hu, Jinming, Liu, Shiyong
Format:	Artikel
Sprache:	eng
Schlagworte:	aggregation-induced emission (AIE) Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology antimicrobial agents Bacteria bacterial detection Cationic Cell Membrane Permeability - drug effects Copolymers Emission Escherichia coli - cytology Escherichia coli - drug effects Escherichia coli - isolation & purification Fluorescent Dyes - chemistry Fluorescent Dyes - pharmacology Fluorometers Heterocyclic Compounds, 1-Ring - chemistry Hydrophobic and Hydrophilic Interactions Inhibition Magnetic Phenomena Magnetic resonance magnetic resonance (MR) imaging Polymers - chemistry Polymers - pharmacology star copolymers Strain
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Beschreibung
Zusammenfassung:	Four‐arm star‐shaped copolymers, TPE‐star‐P(DMA‐co‐BMA‐co‐Gd), containing TPE cores with an aggregation‐induced emission (AIE) feature, a T 1‐type magnetic resonance (MR) contrast agent, and amphiphilic cationic arms, are synthesized. By taking advantage of non‐covalent interactions between star copolymers and bacteria surfaces, bimodal fluorometric/MR detection and concomitant inhibition of both Gram‐positive and Gram‐negative bacteria strains in aqueous media are explored.
ISSN:	0935-9648 1521-4095
DOI:	10.1002/adma.201402797