Preparation and application of hydrophilic monolithic columns

Hydrophilic interaction chromatography (HILIC) has experienced increasing attention in recent years. Much research has been carried out in the area of HILIC separation mechanisms, column techniques and applications. Because of their good permeability, low resistance to mass transfer and easy prepara...

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Veröffentlicht in:	Journal of Chromatography A 2011-04, Vol.1218 (17), p.2350-2361
Hauptverfasser:	Jiang, Zhengjin, Smith, Norman William, Liu, Zhenghua
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Analytical, structural and metabolic biochemistry Biological and medical sciences Capillaries Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography Chromatography, Liquid - instrumentation Chromatography, Liquid - methods Exact sciences and technology Fundamental and applied biological sciences. Psychology General aspects, investigation methods Humans Hydrophilic interaction chromatography Hydrophobic and Hydrophilic Interactions Low resistance Mass transfer Monolithic column Other chromatographic methods Permeability Phases Polymer based monolith Polymers - chemistry Proteins Separation Silica based monolith Silicon Dioxide - chemistry Trends
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Beschreibung
Zusammenfassung:	Hydrophilic interaction chromatography (HILIC) has experienced increasing attention in recent years. Much research has been carried out in the area of HILIC separation mechanisms, column techniques and applications. Because of their good permeability, low resistance to mass transfer and easy preparation within capillaries, hydrophilic monolithic columns represent a trend among novel HILIC column techniques. This review attempts to present an overview of the preparation and applications of HILIC monolithic columns carried out in the past decade. The separation mechanism of various hydrophilic monolithic stationary phases is also reviewed.
ISSN:	0021-9673 1873-3778
DOI:	10.1016/j.chroma.2011.02.024