Development of a Biopolymer by Chemical Modification of ?-Cyclodextrin for Pharmaceutical Applications

The need for effective and safe therapeutic systems comply deliverances medication with the patient, led to the development of new tools and strategies. Cyclodextrins (CDs) are widely used as an excipient in many pharmaceutical forms. In this work, the beta -cyclodextrin ( beta -CD) has been modified in order to serve as a vehicle for the design of capsules with diclofenac sodium (DCFNa) is the active ingredient. This modification is based on the crosslinking of the beta -cyclodextrin by citric acid in the presence of a catalyst. Modulation parameters of the reaction were carried out by varying the content of the polyacid and used this in order to have the best reaction yield. The resulting matrix of this method was used to prepare the inclusion complexes with the drug. The characterization of these systems is performed by FTIR spectroscopy and XRD. Then, the release of DCFNa (packed in capsules), from native and cross-linked matrices in a simulated gastric and intestinal environment (pH = 1.2, t = 2 h) and (pH = 6.8, t = 6 h), was done. The kinetics of drug were studied and the dissolution profiles for the cross-linked and native beta -CD were compared.