Pd-Catalyzed C-H activation/oxidative cyclization of acetanilide with norbornene: concise access to functionalized indolines

Pd-Catalyzed C-H activation/oxidative cyclization of acetanilide with norbornene: concise access to functionalized indolines

An efficient Pd-catalyzed oxidative cyclization reaction for the synthesis of functionalized indolines by direct C-H activation of acetanilide has been developed. The norbornylpalladium species formed via direct ortho C-H activation of acetanilides is supposed to be a key intermediate in this transf...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2014-08, Vol.50 (61), p.8370-8373
Hauptverfasser: Gao, Yang, Huang, Yubing, Wu, Wanqing, Huang, Kefan, Jiang, Huanfeng
Format: Artikel
Sprache:eng
Schlagworte:
Acetanilide
Acetanilides - chemistry
Activation
Carbon - chemistry
Catalysis
Crystallography, X-Ray
Cyclization
Hydrogen - chemistry
Indoles - chemistry
Molecular Conformation
Norbornanes - chemistry
Oxidation-Reduction
Palladium
Palladium - chemistry
Synthesis
Transformations
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Zusammenfassung:An efficient Pd-catalyzed oxidative cyclization reaction for the synthesis of functionalized indolines by direct C-H activation of acetanilide has been developed. The norbornylpalladium species formed via direct ortho C-H activation of acetanilides is supposed to be a key intermediate in this transformation.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc03062a