Effect of locust poison on neuromembrane functional activity

1. The effect of locust poison (LP) on membrane excitability, chemosensitivity and Na-K pump activity was studied. 2. LP in a concentration of 10(-4) mg/ml has a potential independent blocking effect on neuromembrane excitability. 3. LP has an activation effect on Na-K pump-induced membrane hyperpol...

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Veröffentlicht in:	General pharmacology 1997-10, Vol.29 (4), p.587-590
Hauptverfasser:	SAGHYAN, A, HUNANIAN, A, AYRAPETYAN, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Analgesics Animal poisons toxicology. Antivenoms Animals Biological and medical sciences Grasshoppers Helix (Snails) In Vitro Techniques Medical sciences Membrane Potentials - drug effects Neurons - drug effects Neuropharmacology Neurotoxins - pharmacology Patch-Clamp Techniques Pharmacology. Drug treatments Poisons - pharmacology Sodium-Potassium-Exchanging ATPase - drug effects Toxicology
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Zusammenfassung:	1. The effect of locust poison (LP) on membrane excitability, chemosensitivity and Na-K pump activity was studied. 2. LP in a concentration of 10(-4) mg/ml has a potential independent blocking effect on neuromembrane excitability. 3. LP has an activation effect on Na-K pump-induced membrane hyperpolarization. 4. In a concentration higher than 10(-4) mg/ml, LP leads to a decrease in the acetylcholine-induced current and to an increase in this current after the washout of LP from the medium.
ISSN:	0306-3623 1879-0011
DOI:	10.1016/S0306-3623(96)00469-7