Indole Alkaloid Glycosides from the Aerial Parts of Strobilanthes cusia

Three indole alkaloid glycosides, strobilanthosides A–C (1–3), two known indole alkaloid glucosides (4 and 5), and five phenylethanoid glycosides (8–10) were isolated from the aerial parts of Strobilanthes cusia. The structures of the new compounds were elucidated by spectrometric analysis, and the...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2014-12, Vol.77 (12), p.2590-2594
Hauptverfasser:	Gu, Wei, Zhang, Yu, Hao, Xiao-Jiang, Yang, Fu-Mei, Sun, Qian-Yun, Morris-Natschke, Susan L, Lee, Kuo-Hsiung, Wang, Yue-Hu, Long, Chun-Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acanthaceae - chemistry Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - pharmacology Glycosides - chemistry Glycosides - isolation & purification Glycosides - pharmacology Indole Alkaloids - chemistry Indole Alkaloids - isolation & purification Indole Alkaloids - pharmacology Microbial Sensitivity Tests Molecular Structure Nuclear Magnetic Resonance, Biomolecular Staphylococcus aureus - drug effects
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Zusammenfassung:	Three indole alkaloid glycosides, strobilanthosides A–C (1–3), two known indole alkaloid glucosides (4 and 5), and five phenylethanoid glycosides (8–10) were isolated from the aerial parts of Strobilanthes cusia. The structures of the new compounds were elucidated by spectrometric analysis, and the absolute configurations of 1 and 2 were established by ECD spectrocsopy. N′-β-d-Glucopyranosylindirubin (5) showed weak antibacterial activity (MIC 62.5–125 μM) against Staphylococcus aureus.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np5003274