Dendritic alterations in cortical pyramidal cells in the sparse fur mouse

Ornithine carbamoyltransferase deficiency, an X-linked trait, leads to toxic hyperammonemia in sparse fur ( spf/Y) mice. Quantitative analysis of the basilar dendritic tree of layer V pyramidal cells in frontoparietal cortex stained by the Golgi Kopsch method revealed a significant decrease in both...

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Veröffentlicht in:	Brain research 1998-06, Vol.797 (1), p.167-172
Hauptverfasser:	Hopkins, Keri J, McKean, J, Mervis, Ronald F, Oster-Granite, Mary Lou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Size Cerebral Cortex - enzymology Cerebral Cortex - pathology Dendrites - pathology Errors of metabolism Golgi Kopsch Male Medical sciences Metabolic diseases Mice Mice, Mutant Strains Miscellaneous hereditary metabolic disorders Ornithine Carbamoyltransferase - genetics Ornithine carbamoyltransferase deficiency Pyramidal Cells - enzymology Pyramidal Cells - pathology Pyramidal Cells - ultrastructure Sholl analysis Sparse fur
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Zusammenfassung:	Ornithine carbamoyltransferase deficiency, an X-linked trait, leads to toxic hyperammonemia in sparse fur ( spf/Y) mice. Quantitative analysis of the basilar dendritic tree of layer V pyramidal cells in frontoparietal cortex stained by the Golgi Kopsch method revealed a significant decrease in both the complexity of the dendritic arbor and in dendritic terminal spine density (60%) in spf/Y mice compared with controls. Such reductions may contribute to behavioral dysfunction observed in spf/Y mice.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/S0006-8993(98)00392-8