Overexpression of GOLPH3 protein is associated with worse prognosis in patients with epithelial ovarian cancer

Overexpression of GOLPH3 protein is associated with worse prognosis in patients with epithelial ovarian cancer

Golgi phosphoprotein 3 (GOLPH3) has important roles in the pathogenesis of cancer, and overexpression of GOLPH3 has been found in several kinds of cancers. However, the relationship between GOLPH3 overexpression and prognosis in patients with epithelial ovarian cancer remains unknown. This study aim...

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Veröffentlicht in:Tumor biology 2014-12, Vol.35 (12), p.11845-11849
Hauptverfasser: Ma, Yingchun, Wang, Xiuxia, Wu, Yuanhong, Sun, Binghui, Lv, Hongtao, Rong, Fengnian, Zheng, Xiaoxia
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Biomedicine
Cancer Research
Carcinoma, Ovarian Epithelial
Female
Gene Expression
Humans
Immunohistochemistry
Medical prognosis
Membrane Proteins - genetics
Membrane Proteins - metabolism
Middle Aged
Neoplasm Grading
Neoplasm Metastasis
Neoplasm Staging
Neoplasms, Glandular and Epithelial - diagnosis
Neoplasms, Glandular and Epithelial - metabolism
Neoplasms, Glandular and Epithelial - mortality
Neoplasms, Glandular and Epithelial - surgery
Ovarian cancer
Ovarian Neoplasms - diagnosis
Ovarian Neoplasms - metabolism
Ovarian Neoplasms - mortality
Ovarian Neoplasms - surgery
Prognosis
Protein expression
Research Article
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Zusammenfassung:Golgi phosphoprotein 3 (GOLPH3) has important roles in the pathogenesis of cancer, and overexpression of GOLPH3 has been found in several kinds of cancers. However, the relationship between GOLPH3 overexpression and prognosis in patients with epithelial ovarian cancer remains unknown. This study aimed to investigate the relationship between GOLPH3 overexpression and overall survival in patients with epithelial ovarian cancer. The expression of GOLPH3 protein in tumor tissue was evaluated using immunohistochemistry. Seventy-five patients with epithelial ovarian cancer with the data of GOLPH3 expression and follow-up were included. GOLPH3 overexpression was significantly associated with advanced stage, histology, high grade, and lymph node metastases ( P  
ISSN:1010-4283
1423-0380
DOI:10.1007/s13277-014-2411-1